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國立陽明交通大學傳統醫藥研究所

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蔡東湖 教授

 

姓名:蔡東湖

職稱:國立陽明大學 醫學院 傳統醫藥所教授

電話:(02) 2826 7115

傳真:(02) 2822 5044

地址:11221台北市立農街二段155號

電子信箱:thtsai@ym.edu.tw

https://www.scopus.com/authid/detail.uri?authorId=7401925691

學經歷:

台北醫學院 藥學士

國立陽明大學 藥理學碩士

國立陽明大學 藥理學博士

英國劍橋大學 博士後研究

2010/8 - 2010/12, 國立陽明大學 教授兼副國際長

2009 -2015國立陽明大學 傳統醫藥學研究所教授兼所長

2005 - 國立陽明大學 傳統醫藥學研究所教授

1999 - 2005國立中國醫藥研究所 研究員兼組長

2005 -中國醫藥大學 針灸研究所兼任教授

2014 -高雄醫藥大學 藥學系合聘教授

2005 -台北榮民綜醫院兼任研究員

2005 -2010台北市立聯合醫院 教研部 研究發展組主任

2010 -2015台北市立聯合醫院 教研部主任

2016 -2020 國立聯合大學 校長

科學期刊編審工作:

Editor, John Wiley & Sons, Inc. Chief Editor for the book of Application of Microdialysis in Pharmaceutical Science 2011

Academic Guest Editor, Molecules (SCI) 2017

Editorial Board, Journal of Pharmaceutical and Biomedical Analysis. (SCI) from 2009-

Editorial Board, Biomedical Chromatography. (SCI) from 2012-

Editorial Board, Journal of Chromatography B. (SCI) from 2012-

學術獎項:

2007-2015       國立陽明大學教師學術卓越獎勵

2007, 2014      國立陽明大學優良教師獎

2007 Top referee, Journal of Pharmaceutical and Biomedical Analysis

2008 Top referee, Journal of Chromatography B

2017 June Outstanding contribution in reviewing Phytomedicine

2018 November Outstanding contribution in reviewing Journal of Chromatography B

2018 November Outstanding contribution in reviewing Journal of Pharmaceutical and Biomedical Analysis

學術研究計畫審查、評鑑、典試委員

高等教育評鑑中心 高等教育評鑑委員

考選部 高等考試典試委員

香港大學 研究計畫海外審查委員

國家科學委員會 專題研究計畫初審及複審委員

奧地利 研究計畫審查委員

發表論文數: 374; 論文被引用總數: 10516篇次; h-index 50 (October 7, 2020)

Affiliation: National Yang-Ming University Taiwan, Taipei, Taiwan

Author ID: 7401925691; E-mail: thtsai@ym.edu.tw

https://www.scopus.com/authid/detail.uri?authorId=7401925691

國內外學術期刊與研究審查委員:

1. African Journal of Pharmacy and Pharmacology; 2. The American Journal of Chinese Medicine; 3. Analytica Chimica Acta; 4. Autonomic Neuroscience; 5. Biomedical Engineering; 6. British Journal of Pharmacology; 7. Cancer Biotherapy & Radiopharmaceuticals; 8. Chromatographia; 9. Colloids and Surfaces B: Biointerfaces; 10. Current Pharmaceutical Analysis; 11. European Journal of Pharmaceutical Science; 12. Expert Opinion On Drug Metabolism and Toxicology; 13. International Journal of Pharmaceutics; 14. Journal of Agriculture Food and Chemistry; 15. Journal of Biochemical and Biophysical Methods; 16. Journal of Biomedical Nanotechnology; 17. Journal of Chromatography A; 18. Journal of Chromatography B; 19. Journal of Medicinal Plants Research; 20. Journal of Natural Products; 21. Journal of Orthopaedic Surgery and Research; 22. Journal of Pharmacy and Pharmacology; 23. Journal of Pharmaceutical and Biomedical Analysis; 24. Journal of Pharmaceutical Sciences; 25. Journal of Separation Science; 26. Journal of Traditional and Complementary Medicine;; 27. Journal of Zhejiang University-SCIENCE B.; 28. Life Sciences; 29. Methods and Findings in Experimental and Clinical Pharmacology; 30. Molecular Nutrition and Food Research; 31. Molecules; 32. Nutrition Research; 33. Planta Medica; 34. PlosOne; 35. Pharmaceutical Research; 36. Pharmacological Report; 37. Phytochemical Analysis; 38. Rapid Communications in Mass Spectrometry; 39. Regulatory Toxicology and Pharmacology; 40. Research in Veterinary Science; 41. Talanta 

研究論文 PUBLICATIONS (REFEREE PAPER)

1. Tsai, T.H., Chen, C.F. (1991) Determination of three active principles in licorice extract by reversed-phase high-performance liquid Chromatography. Journal of Chromatography. 542:521-525. (SCI)

2. Tsai, T.H., Chen, C.F. (1991) High-performance liquid chromatographic determination of 18-alpha-glycyrrhetinic acid and 18-beta-glycyrrhetinic acid in rat plasma: application to pharmacokinetic study. Journal of Chromatography. 567:405-414. (SCI)

3. Tsai, T.H., Chen, C.F. (1991) Atlas of Chromatograms of glycyrrhizin, 18-alpha-glycyrrhetinic acid and 18-beta-glycyrrhetinic acid from licorice. Journal of Chromatography Science. 29:368. (SCI)

4. Tsai, T.H., Chen, C.M., Chen, C.F. (1992) Disposition of asarone after intravenous administration to rabbits assessed using HPLC. Journal of Pharmacy and Pharmacology. 44:620-623. (SCI)

5. Tsai, T.H., Liao, J.F., Yang, H.Y., Chen, C.F. (1992) Effects of licorice and its active principles on carrageenan-induced edema of the rat hind-paw. Journal of Chinese Medicine. 3:33-39.

6. Tsai, T.H., Chen, C.F. (1992) Ultraviolet spectrum identification of ferulic acid in rabbit plasma by HPLC and its pharmacokinetics application. International Journal Pharmaceutics. 80: 75-79. (SCI)

7. Tsai, T.H., Chen, C.F. (1992) Ultraviolet spectrum identification of emodin in rabbit plasma by HPLC and its pharmacokinetics application. Asia Pacific Journal of Pharmacology. 7: 53-56. (SCI)

8. Tsai, T.H., Chen, C.F. (1992) Determination of glycyrrhizin in rabbit plasma by high-performance liquid chromatography with photodiode-array ultraviolet detection and its pharmacokinetics application. Journal of Chromatography. 576: 170-173. (SCI)

9. Tsai, T.H., Chen, C.F. (1992) Identification and determination of honokiol and magnolol from Magnolia officinalis by high-performance liquid chromatography with photodiode-array UV detection. Journal of Chromatography. 598: 143-146. (SCI)

10. Tsai, T.H., Liao, J.F., Shum A.Y.C., Chen, C.F. (1992) Pharmacokinetics of glycyrrhizin after intravenous administration to rats. Journal of Pharmaceutical Sciences. 81: 961-963. (SCI)

11. Tsai, T.H., Shen, C.C., Chen, C.F. (1992) Determination and ultraviolet spectrum identification of 18-α-glycyrrhetinic acid and 18-β-glycyrrhetinic acid for stability studies. International Journal of Pharmaceutics. 84: 279-281. (SCI)

12. Tsai, T.H., Chou, C.J., Lin, L.C., Tsai, W.J., Chen, C.F. (1993) Determination of aristolochic acid in rabbit plasma by high-performance liquid chromatography with photodiode array ultraviolet detection and its pharmacokinetics application. Journal of Liquid Chromatography. 16: 1173-1182. (SCI)

13. Peng, Y.T., Shum, A.Y.C., Tsai, T.H., Lin, L.C., Chen, C.F. (1993) High-performance liquid chromatography of the quinazolinocarboline alkaloid dehydroevodiamine. Journal of Chromatography. 617: 87-93. (SCI)

14. Tsai, T.H., Chen, C.F. (1994) Simultaneous measurement of acetylcholine and monoamines by two serial on-line microdialysis systems: effects of methamphetamine on neurotransmitters release from the striatum of freely moving rats. Neuroscience Letters. 166: 175-177. (SCI)

15. Tsai, T.H., Westly, J., Lee, T.F., Chen, C.F. (1994) Identification and determination of geniposide, genipin, gardenoside and geniposidic acid form herbs by HPLC/photodiode-array detection. Journal of Liquid Chromatography. 17: 2199-2205. (SCI)

16. Cheng, F.C., Kuo, J.S., Chia, L.G., Tsai, T.H., Chen, C.F. (1994) Rapid measured of the monoamine content in small volumes of rat plasma. Journal of Chromatography B. 654: 177-183. (SCI)

17. Tsai, T.H., Chou, C.J., Cheng, F.C., Chen, C.F. (1994) Pharmacokinetics of honokiol after intravenous administration in rats assessed using high-performance liquid chromatography. Journal of Chromatography B. 655: 41-45. (SCI)

18. Ko, H.C., Tsai, T.H., Chou, C.J., Hsu, S.Y., Li, S.Y., Chen, C.F. (1994) High-performance liquid chromatographic determination of rutaecarpine in rat plasma: application to pharmacokinetic study. Journal of Chromatography B. 655: 27-31. (SCI)

19. Tsai, T.H., Chou, C.J., Chen, C.F. (1994) Disposition of magnolol after intravenous bolus and infusion in rabbit. Drug Metabolism and Disposition. 22: 518-521. (SCI)

20. Tsai, T.H., Chou, C.J., Chen, C.F. (1994) Pharmacokinetics of paeonol after intravenous administration to rats. Journal of Pharmaceutical Sciences. 83: 1307-1309. (SCI)

21. Lee, T.F., Tsai, T.H., Chen, C.F., Wang, L.C.H. (1994) Thermoregulatory effects after intracerebroventricular injections of wu-chu-yu extracts in rats. Thermal Balance in Health and Disease. 136: 481-484.

22. Tsai, T.H., Lee, T.F., Chen, C.F., Wang, L.C.H. (1995) Thermoregulatory effects of alkaloids isolated from wu-chu-yu in afebrile and febrile rats. Pharmacology Biochemistry and Behavior. 50: 293-298. (SCI)

23. Shyr, M.H., Tsai, T.H., Tan, P.P.C., Chen, C.F., Chan, S.H.H. (1995) Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat. Neuroscience Letters. 184: 212-215. (SCI)

24. Tsai, T.H., Lee, T.F., Chen, C.F., Wang, L.C.H. (1995) Modulatory effects of magnolol on potassium stimulated 5-HT release from rat cortical and hippocampal slices. Neuroscience Letters. 186: 49-52. (SCI)

25. Tsai, T.H., Tsai, W.J., Chou, C.J., Chen, C.F. (1995) Magnolol inhibits collagen-induced platelet serotonin release. Thrombosis Research. 78: 265-270. (SCI)

26. Tsai, T.H., Tsai, W.J., Chou, C.J., Chen, C.F. (1995) Inhibition by honokiol of collagen-induced platelet 5-HT release. Pharmaceutical Sciences. 1: 243-245.

27. Tsai, T.H., Chou, C.J., Chen, C.M., Chen, C.F. (1995) Determination of magnolol in rat plasma by HPLC/fluorescence. Chinese Pharmaceutical Journal. 47:207-212.

28. Jeng, K.F., Lin, Y.H., Lin, L.C., Chou, C.J., Tsai, T.H., Chen, C.F. (1995) High-performance liquid chromatographic determination of evodiamine in rats plasma: application to pharmacokinetic study. Journal of Chromatography B. 668: 343-345. (SCI)

29. Tsai, T.H., Tsai, W.J., Chen, C.F. (1995) Aspirin inhibits collagen-induced platelet serotonin, measured by microbore high-performance liquid chromatography electrochemical detection. Journal of Chromatography B. 669: 404-407. (SCI)

30. Tsai, T.H., Westly, J., Lee, T.F., Chen, C.F., Wang, L.C.H. (1995) Effects of honokiol and magnolol on acetylcholine and norepinephrine from rat hippocampal slices. Planta Medica. 61: 477-479. (SCI)

31. Tsai, T.H., Chou, C.J., Chen, C.F. (1995) Glucuronidation of magnolol assessed using HPLC/fluorescence. Planta Medica. 61: 491-492. (SCI)

32. Chang, A.Y.W., Kuo, T.B.J., Tsai, T.H., Chen, C.F., Chan, S.H.H. (1995) Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with evaluation of noradrenergic neurotransmission at the medial prefrontal cortex. Synapse. 21: 149-157. (SCI)

33. Tsai, T.H., Chou, C.J., Chen, C.F. (1996) Pharmacokinetic and brain distribution of magnolol in the rats after intravenous bolus injection. Journal of Pharmacy and Pharmacology. 48: 57-59. (SCI)

34. Tsai, T.H.*, Chou, C.J., Tsai, W.J., Chen, C.F. (1996) Magnolol inhibits arachidonic acid-induced rabbit platelet serotonin release, measure by microbore HPLC with electrochemical detection. Journal of Liquid Chromatography. 19: 949-955. (SCI)

35. Tsai, T.H.*, Hsu, S.Y., Chou, C.J., Tsai, T.R., Chen, C.F. (1996) Determination of dihydro-5,6-dehydrokawain in rat plasma by HPLC and its pharmacokinetics application. Journal of Liquid Chromatography. 19: 1127-1137. (SCI)

36. Tsai, T.H., Chen, C.F. (1996) An in vivo microdialysis determination of collagen-induced serotonin release in rat blood. Journal of Chromatography A. 730: 121-123. (SCI)

37. Wang, H., Kuo, T.B.S., Chan, S.H.H. Tsai, T.H., Lee, T.Y., Lui, P.W. (1996) Spectral analysis of arterial pressure variability during induction of propofol anesthesia. Anesthesia and Analgesia. 82: 914-919. (SCI)

38. Tsai, T.R., Cham, T.M., Chen, K.C., Chen, C.F., Tsai, T.H.* (1996) Determination of acetylcholine by on-line microdialysis coupled with pre- and post-microbore column enzyme reactors with electrochemical detection. Journal of Chromatography B. 678: 151-155. (SCI)

39. Tsai, T.H.*, Tsai, T.R., Chen, C.C., Chen, C.F. (1996) Determination of osthole in rat plasma by HPLC and its pharmacokinetics application. Journal of Pharmaceutical and Biomedical Analysis. 14: 749-753. (SCI)

40. Tsai, T.H.*, Tsai, T.R., Chou, C.J., Chen, C.F. (1996) Determination of dicentrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetics. Journal of Chromatography B. 681:277-281. (SCI)

41. Tsai, T.H.*, Chou, C.J., Tsai, T.R., Chen, C.F. (1996) Determination of wogonin in rat plasma by HPLC and its Pharmacokinetics application. Planta Medica. 62:263-266. (SCI)

42. Chou, C.Y.C., Tsai, T.H., Lin, M.F., Chen, C.F. (1996) Simultaneous determination of honokiol and magnolol in Magnolia officinalis by capillary zone electrophoresis. Journal of Liquid Chromatography. 19:1909-1915. (SCI)

43. Wang, Y.H., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1996) Determination of triacylglycerols in Panax pseudo-ginseng by HPLC polymeric column. Journal of Liquid Chromatography. 19:2497-2503. (SCI)

44. Tsai, T.H.*, Kuo, K.W., Cheng, F.C., Chen, C.F. (1996) Determination of scoparone in rat plasma by liquid chromatography and it application to pharmacokinetics. Journal of Liquid Chromatography. 19:2649-2657. (SCI)

45. Tsai, T.H.* (1996) The technology and pharmaceutical analysis microbore column liquid chromatography. Chemistry. 54:111-117.

46. Tsai, T.H.*, Chou, C.J., Lee, T.F., Wang, L.C.H., Chen, C.F. (1996) Pharmacokinetic and pharmacodynamic studies of magnolol after oral administration in rats. Pharmaceutical Sciences. 2:191-193.

47. Wang, Y.H., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1996) Determination of trilinolein in the vasoactive and antithrombotic herbs by HPLC. Journal of Chinese Medicine. 7:203-210.

48. Tsai, T.H.*, Chen, C.F., Cheng, F.C., Kuo, K.W., Tsai, T.R. (1997) Analysis and pharmacokinetics of apomorphine in rat brain by microdialysis coupled with microbore HPLC electrochemical detection. Journal of Liquid Chromatography. 20:481-490. (SCI)

49. Tsai, T.H.*, Chen, C.F. (1997) Measurement and pharmacokinetic analysis of buspirone brain microdialysis coupled with electrochemical detection. Journal of Chromatography A. 762:269-273. (SCI)

50. Wang, Y.H., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1997) Determination of trilinolein and 1,2-dilinoleoyl-3-oleoyl-glycerol in various Panax ginseng by HPLC. Journal of Liquid Chromatography. 20:899-905. (SCI)

51. Tsai, T.H.*, Matthews, C.A., Chen, C.F. (1997) Aromatherapy. Journal of Chinese Medicine. 8:23-32.

52. Huang, S.S., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1997) Identification of magnolol and honokiol in the stem and leave of Magnolia gradiflora L. and Magnolia coco (Lour.) DC. by liquid chromatography. Journal of Chinese Medicine. 8:55-61.

53. Shyr, M.H., Tsai, T.H., Yang, C.H., Chen, H.M., Ng, H.F., Tan, P.P.C. (1997) Propofol anesthesia increases dopamine and serotonin actives at the somatosensory cortex in rats: a microdialysis. Anesthesia Analgesia. 84:1344-1348. (SCI)

54. Tsai, T.H.*, Matthews, K., Dalley, J.W. (1997) Determination of glutamate in rat brain microdialysates by microbore liquid chromatography with electrochemical detection. Journal of Liquid Chromatography. 20:3039-3047. (SCI)

55. Tsai, T.H.*, Hong, C.Y., Chen, C.F. (1997) Analysis of active ingredients in medicine herbs with high-performance liquid chromatography and related technologies: a review. Journal of Food and Drug Analysis. 5:303-317. (SCI)

56. Chang, C.C., Huang, H.C., Tsai, T.H., Chen, C.F. (1997) Determination of tetrandrine with high-performance liquid chromatography and its application to pharmacokinetic study in rats. Journal of Chinese Medicine. 8:229-236.

57. Wu, Y.S., Ho, W.M., Tsai, T.H., Yang, L.L., Kuo, J.S., Cheng, F.C. (1997) Monitoring of blood catecholamines by microdialysis and microbore liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 16:77-85. (SCI)

58. Peng, H.W., Huang, Y.T., Chen, C.F., Tsai, T.H.* (1997) Validation of liquid chromatographic method in herbal medicine analysis. Journal of Chinese Medicine. 8:237-244.

59. Tsai, T.H.*, Chen, C.F. (1997) HPLC assessment of esculetin glucuronidation. Chinese pharmaceutical Journal. 49:321-324.

60. Peng, H.W., Cheng, F.C., Huang, Y.T., Chen, C.F., Tsai, T.H.* (1998) Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography. Journal of Chromatography B. 714:369-374. (SCI)

61. Huang, C.T., Chen, K.C., Chen, C.F., Tsai, T.H.* (1998) Simultaneous measurement of blood and brain microdialysates of granisetron in rat by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B. 716:251-255. (SCI)

62. Peng, H.W., Huang, Y.T., Chen, C.F., Tsai, T.H.* (1998) Glucuronidation of naringenin in rat. Planta Medica. 64:779. (SCI)

63. Tsai, T.H.*, Cheng, F.C., Hung, L.C., Chen, C.F. (1998) On-line microdialysis coupled with microbore liquid chromatography to measure chloramphenicol and its glucuronide in rat blood. Journal of Chromatography B. 720:165-169. (SCI)

64. Cheng, F.C., Tsai, T.H.*, Wu, Y.S., Kuo, J.S., Chen, C.F. (1999) Pharmacokinetic and pharmacodynamic analyses of trazodone in rat striatum by in vivo microdialysis. Journal of Pharmaceutical and Biomedical Analysis. 19:293-300. (SCI)

65. Liang, C.C., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1999) Measurement and pharmacokinetic study of tetramethylpyrazine in rat blood and its regional brain tissue by high-performance liquid chromatography. Journal of Chromatography B. 724: 303-309. (SCI)

66. Dalley J.M., Thomas, K.L., Howes, S.R., Tsai, T.H., Aparicio-Legarza, M.I., Reynolds, G.P., Everitt, B.J., Robbins, T.W. (1999) Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens. European Journal of Neuroscience. 11:1265-1274. (SCI)

67. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Pharmacokinetic study of granisetron in rat blood and brain by microdialysis. Life Sciences. 64:1921-1931. (SCI)

68. Liang, C.C., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1999) Regional brain distribution of tetramethylpyrazine in rat. Journal of Chinese Medicine. 10:117-123.

69. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Pharmacokinetics and brain regional distribution of caffeine in rats. Journal of Chinese Medicine. 10:125-133.

70. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Determination of caffeine content in the tea and coffee. Journal of Chinese Medicine. 10:135-141.

71. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Measurement and pharmacokinetic study of unbound tropisetron in rat blood by microdialysis with high-performance liquid chromatography. International Journal of Pharmaceutics. 182:237-242. (SCI)

72. Tsai, T.H.*, Chen, Y.F., Chen, I.F., Chen, C.F. (1999) Measurement of unbound caffeic acid in rat blood by on-line microdialysis coupled with liquid chromatography and its application to pharmacokinetic studies. Journal of Chromatography B. 729:119-125. (SCI)

73. Tsai, T.H.*, Hung, L.C., Chen, C.F. (1999) Biliary excretion of chloramphenicol and chloramphenicol glucuronide in rat by microdialysis. Journal of Pharmacy and Pharmacology. 51:911-915. (SCI)

74. Tsai, T.H.*, Huang, C.T., Shum, A.Y.C., Chen, C.F. (1999) Pharmacokinetic and biliary excretion study of esculetin by microdialysis in rat. Life Sciences. 65:1647-1655. (SCI)

75. Tsai, T.H.*, Tsai, T.R., Chen, Y.F., Chou, C.J., Chen, C.F. (1999) Determination of unbound 20(S)-camptothecin in rat bile by on-line microdialysis coupled to microbore liquid chromatography with fluorescence detection. Journal of Chromatography B. 732:221-225. (SCI)

76. Liang, C.C., Hong, C.Y., Chen, C.F., Tsai, T.H.* (1999) Determination of tetramethylpyrazine in the herbs of chuanxiong and yujin by high-performance liquid chromatography. Journal of Chinese Medicine. 10:205-212.

77. Tsai, T.H.*, Hung, L.C., Shum, A.Y.C., Chen, C.F. (1999) Pharmacokinetic study of unbound chloramphenicol in rat blood and brain by microdialysis. Chinese Pharmaceutical Journal. 51:287-298.

78. Huang, C.T., Chen, C.F., Tsai, T.H.* (1999) Biliary excretion of granisetron by microdialysis coupled to HPLC with fluorescence detection. Journal of Liquid Chromatography and Related Technologies. 22:2815-2823. (SCI)

79. Tsai, T.H.*, Cheng, F.C., Hung, L.C. Chen, C.F. (1999) Measurement of hydroxyl radical in rat blood vessels by microbore liquid chromatography and electrochemical detection: a microdialysis study. Journal of Chromatography B. 734:277-283. (SCI)

80. Tsai, T.H.*, Cheng, F.C., Chen, K.C., Chen, Y.F. Chen, C.F. (1999) Simultaneous measurement of cefuroxime in rat blood and brain by microdialysis and microbore liquid chromatography. Journal of Chromatography B. 735:25-31. (SCI)

81. Tsai, T.H.*, Cheng, F.C., Hung, L.C., Chen, C.F. (1999) Determination of unbound ceftriaxone in rat blood by on-line microdialysis and microbore liquid chromatography. International Journal of Pharmaceutics. 193:21-26. (SCI)

82. Tsai, T.R., Cheng, F.C., Hung, L.C., Chen, C.F., Tsai, T.H.* (1999) Measurement of cefmetazole in rat blood by microdialysis coupled to microbore liquid chromatography: a pharmacokinetic application. Journal of Chromatography B. 736:129-134. (SCI)

83. Tsai, T.H.*, Shum, A.Y.C., Chen, C.F. (2000) Enterohepatic circulation of chloramphenicol and its glucuronide in the rat by microdialysis using a hepato-duodenal shunt. Life Sciences. 66:363-370. (SCI)

84. Tsai, T.H.*, Chen, Y.F., Chou, C.J., Chen, C.F. (2000) Measurement and pharmacokinetics unbound 20(S)-camptothecin in rat blood and brain by microdialysis coupled to microbore liquid chromatography with fluorescence detection. Journal of Chromatography A. 870:221-226. (SCI)

85. Cheng, F.C., Yang, L.L., Yang, D.Y., Tsai, T.H., Lee, C.W., Chen, S.H. (2000) Monitoring of extracellular pyruvate, lactic acid, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils. J. Chromatography A. 870:389-394. (SCI)

86. Cheng, F.C., Kuo, J.S., Huang, H.M., Yang, D.Y., Wu, T.F., Tsai, T.H. (2000) Determination of catecholamines in pheochromocytoma cells culture medium by microdialysis - microbore liquid chromatography. Journal of Chromatography A. 870:405-411. (SCI)

87. Tsai, T.H.*, Chen, Y.F., Shum, A.Y.C., Chen, C.F. (2000) Determination of chlorogenic acid in rat blood by microdialysis coupled with microbore liquid chromatography in pharmacokinetic application. Journal of Chromatography A. 870:443-448. (SCI)

88. Tsai, T.H.*, Chen, Y.F., Chen, K.C., Shum, A.Y.C., Chen, C.F. (2000) Concurrent quantification and pharmacokinetic analysis of cefotaxime in rat blood and brain by microdialysis and microbore liquid chromatography. Journal of Chromatography B. 738:75-81. (SCI)

89. Tsai, T.H.*, Tsai, T.R., Chen, Y.F. Chen, C.F. (2000) Determination and pharmacokinetic study of unbound cefoxitin in rat blood and brain with on-line microdialysis and microbore liquid chromatography. Analytica Chimica Acta. 412:13-18. (SCI)

90. Tsai, T.H.*, Hung, L.C., Chang, Y.L., Shum, A.Y.C., Chen, C.F. (2000) Simultaneous blood and brain sampling of cephalexin in the rat by microdialysis and microbore liquid chromatography: application to pharmacokinetics studies. Journal of Chromatography B. 740:203-209. (SCI)

91. Chang, Y.L., Chen, Y.F., Chen, C.F., Tsai, T.H.* (2000) Determination of unbound cephalothin in rat blood by on-line microdialysis and microbore liquid chromatography. Journal of Chromatography B. 742:125-130. (SCI)

92. Tsai, T.H.*, Chen, Y.F. (2000) Simultaneous blood and brain sampling and analysis of cefazolin in the rat by microdialysis and microbore liquid chromatography. Biomedical Chromatography. 14:274-278. (SCI)

93. Tsai, T.H.*, Tung, H.H., Hung, L.C., Cheng, F.C., Chen, C.F. (2000) Measurement of cimetidine in rat blood by microdialysis and liquid chromatography: a pharmacokinetic application. Journal of Liquid Chromatography and Related Technologies. 23:1599-1608. (SCI)

94. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, Y.F., Chen, C.F., Cheng, F.C., Tsai, T.H.* (2000) Simultaneous determination of unbound cefoperazone in rat blood and brain using microdialysis. Journal of Pharmacy and Pharmacology. 52:963-968. (SCI)

95. Tsai, T.H.* (2000) Separation methods used in choline and acetylcholine assay. Journal of Chromatography B. 747:111-122. (SCI)

96. Tsai, T.H.*, Liu, S.C., Ho, L.K., Chen, C.F. (2000) Determination of unbound ampicillin in rat blood by microdialysis and liquid chromatography. Analytical Letters. 33: 3213-3224. (SCI)

97. Tsai, T.H.*, Chen, Y.F. (2000) Determination of unbound hesperetin in rat blood and brain by microdialysis coupled to microbore liquid chromatography. Journal of Food and Drug Analysis. 8: 331-336. (SCI)

98. Tsai, T.H.*, Kao, H.Y., Chen, C.F. (2001) Measurement and pharmacokinetic analysis of unbound ceftazidime in rat blood by microdialysis and microbore liquid chromatography. Journal of Chromatography B. 750: 93-98. (SCI)

99. Yeh, P.H., Lee, C.H., Cheng, F.C., Tsai, T.H.* (2001) Determination of unbound cefamandole in rat blood by microdialysis and microbore liquid chromatography. Biomedical Chromatography. 15: 14-17. (SCI)

100. Tsai, T.H.* (2001) Effect of ivermectin on the disposition of amoxicillin in rat blood and brain using microdialysis. Analytica Chimica Acta. 431:279-285. (SCI)

101. Matthews, K., Dalley, J., Matthews, C., Tsai, T.H., Robbins, T.W. (2001) Periodic maternal separation of neonatal rats produces regionally and gender specific effects on biogenic amine content in post-mortem adult brain. Synapse. 40: 1-10. (SCI)

102. Tsai, T.H.*, Liang, C.C. (2001) Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis. International Journal of Pharmaceutics. 216: 61-66. (SCI)

103. Wu, Y.S., Tsai, T.H., Wu, T.F., Cheng, F.C. (2001) Determination of pyruvate and lactate in primary liver cell culture medium during hypoxia by on-line microdialysis/liquid chromatography. Journal of Chromatography A. 913: 341-347. (SCI)

104. Yang, D.Y., Tsai, T.H., Cheng, C.H., Lee, C.W., Chen, S.H., Cheng, F.C. (2001) Simultaneous monitoring of extracellular glucose, pyruvate, lactate and glutamate in gerbil cortex during focal cerebral ischemia by dual-probe microdialysis. Journal of Chromatography A. 913: 349-354. (SCI)

105. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, C.F., Tsai, T.H.* (2001) Determination and pharmacokinetic study of unbound cefepime in rat bile and liquid chromatography with on-line microdialysis. Journal of Chromatography A. 914: 77-82. (SCI)

106. Tsai, T.H., Cheng, F.C., Chen, Y.F., Chen, C.F. (2001) On-line microdialysis coupled with microbore liquid chromatography with ultraviolet detection for continuous monitoring of free cefsulodin in rat blood. Journal of Chromatography A. 914: 83-87. (SCI)

107. Tsai, T.H.* (2001) Pharmacokinetics of pefloxacin and its interaction with cyclosporin A, a P-glycoprotein modulator, in rat blood, brain and bile, using simultaneous microdialysis. British Journal of Pharmacology. 132: 1310-1316. (SCI)

108. Tsai, T.H.*, Kao, H.Y., Chen, C.F. (2001) Measurement and pharmacokinetic analysis of unbound cephaloridine in rat blood by on-line microdialysis and microbore liquid chromatography. Biomedical Chromatography. 15: 79-82. (SCI)

109. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, C.F., Tsai, T.H.* (2001) Effect of cyclosporine, P-glycoprotein inhibitor, on the pharmacokinetics of cefepime in rat blood and brain: a microdialysis study. Life Sciences. 69: 191-199.(SCI)

110. Tsai, T.H.*, Wang, L.H., Hung, L.C., Tseng, T.Y., Chen, C.F. (2001) An animal brain microdialysis model for acupuncture study. Journal of Chinese Medicine. 12:129-144.

111. Kau, Y.C., Wong, K.M., Shyr, M.H., Lee, Y.H., Tsai, T.H.* (2001) Simultaneous determination of unbound ropivacaine in rat blood and brain using microdialysis. Journal of Chromatography B. 760:107-112. (SCI)

112. Tsai, T.H.*, Peng, H.W., Chen, C.F. (2001) Enterohepatic circulation of naringenin using paired-rats model. Chinese Pharmaceutical Journal. 53:55-61.

113. Tsai, T.H.* (2001) Analytical approaches for traditional Chinese medicines exhibiting antineoplastic activity. Journal of Chromatography B. 764:27-48. (SCI)

114. Tsai, T.H.*, Wu, J.W. (2001) Pharmacokinetics of ciprofloxacin in the rat and its interaction with cyclosporin A: a microdialysis study. Analytica Chimica Acta. 448:195-199. (SCI)

115. Tsai, T.H.*, Lee, C.H., Yeh, P.H. (2001) Effect of cyclosporin A, a P-glycoprotein modulator, on the pharmacokinetics of camptothecin using microdialysis. British Journal of Pharmacology. 134:1245-1252. (SCI)

116. Chen, Y.J., Shiao, M.S., Hsu, M.L., Tsai, T.H., Wang, S.Y. (2001) The effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells. Journal of Agriculture Food and Chemistry. 49:5615-5619. (SCI)

117. Cheng, F.C., Ho, Y.F., Hung, L.C., Chen, C.F., Tsai, T.H.* (2002) Determination and pharmacokinetic profile of omeprazole in rat blood, brain and bile by microdialysis and high-performance liquid chromatography. Journal of Chromatography A. 949:35-42. (SCI)

118. Liu, S.C., Tsai, T.H.* (2002) Determination of diclofenac in rat bile and its interaction with cyclosporin A using on-line microdialysis coupled to liquid chromatography. Journal of Chromatography B. 769:351-356. (SCI)

119. Chang, Y.L., Chou, M.H., Lin, M.F., Chen, C.F., Tsai, T.H.* (2002) Determination and pharmacokinetic study of meropenem in rat bile with on-line microdialysis and liquid chromatography. Journal of Chromatography A. 961:119-124. (SCI)

120. Tsai, T.R., Tseng, T.Y., Chen, C.F., Tsai, T.H.* (2002) Determination and identification of geniposide contained in Gardenia jasminoides, and in two preparations of mixed traditional Chinese medicines. Journal of Chromatography A. 961:83-88. (SCI)

121. Tsai, P.L., Tsai, T.H.* (2002) Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to liquid chromatography. Journal of Chromatography A. 961:125-130. (SCI)

122. Cheng, F.C., Tsai, T.R., Chen, Y.F., Hung, L.C., Tsai, T.H.* (2002) Determination of levofloxacin in rat blood and bile by microdialysis and high-performance liquid chromatography: a pharmacokinetic study. Journal of Chromatography A. 961:131-136. (SCI)

123. Lee, C.H., Yeh, P.H., Tsai, T.H.* (2002) Hepatobiliary excretion of fluconazole and its interaction with cyclosporin A in rat blood and bile using simultaneous microdialysis. International Journal of Pharmaceutics. 241:367-373 (SCI)

124. Yang, S.E., Hsieh, M.T., Tsai, T.H., Hsu, S.L. (2002) Down-modulation of Bcl-XL, release cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human sequamous lung cancer CH27 cells. Biochemical Pharmacology. 63:1641-1651. (SCI)

125. Cheng, F.C., Jen, C.F., Tsai, T.H.* (2002) Hydroxyl radical in the living systems and its separation methods. Journal of Chromatography B. 781:481-495. (SCI)

126. Tsai, P.L., Tsai, T.H.* (2002) High-performance liquid chromatographic determination of berberine contained in medicinal herbs and a related traditional Chinese medicine. Analytical Letters. 35:2459-2470. (SCI)

127. Tsai, T.H.* (2002) Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin A, a P-glycoprotein modulator. Journal of Agriculture and Food Chemistry. 50:6669-6674. (SCI)

128. Tsai, T.H.*, Liu, S.C., Tsai, P.L., Ho, L.K., Shum, A.Y.C., Chen, C.F. (2002) Pharmacokinetics of baicalein and its interaction with P-glycoprotein inhibitor, cyclosporin A, in the rat: a microdialysis study. British Journal of Pharmacology. 137:1314-1320. (SCI)

129. Yang, S.E., Hsieh, M.T. Hsieh, Tsai, T.H., Hsu, S.L. (2003) Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. British Journal of Pharmacology. 138: 193-201. (SCI)

130. Tsai, T.H.*, Chen, Y.F., Chen, C.F. (2003) Pharmacokinetics of metronidazole in rat blood, brain, and bile studied using microdialysis. Journal of Chromatography A. 987: 277 - 282. (SCI)

131. Lai, L., Lin, L.C., Lin, J.H., Tsai, T.H.* (2003) Pharmacokinetics of mangiferin in rats by microdialysis coupled with microbore high-performance liquid chromatography and tandem mass spectrometry. Journal of Chromatography A. 987:367-374. (SCI)

132. Tsai, T.H.*, Wu, J.W. (2003) Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein and cytochrome P450 using microdialysis. Life Sciences. 72: 2413-2426. (SCI)

133. Wang, G.J., Tseng, H.W., Chou, C.J., Tsai, T.H., Chen, C.T., Lu, M.K. (2003) The vasorelaxation of Antrodia camphorate mycelia: involvement of endothelial Ca2+-NO-cGMP pathway. Life Sciences. 73:2769-2783. (SCI)

134. Tsai, T.H.* (2003) Assaying protein unbound drugs using microdialysis techniques. Journal of Chromatography B. 797:161-173. (SCI)

135. Tsai, T.H.*, Liu, M.C. (2004) Determination and brain distribution of theophylline in rat blood and brain using microdialysis and microbore liquid chromatography. Journal of Chromatography A. 1032:97-101. (SCI)

136. Lin, L.C., Hung, L.C., Tsai, T.H.* (2004) Determination of (-)-epigallocatechin gallate in rat blood using microdialysis coupled with liquid chromatography. Journal of Chromatography A. 1032:125-128. (SCI)

137. Tsai, P.L., Tsai, T.H.* (2004) Hepatobiliary excretion of berberine. Drug Metabolism and Disposition. 32:405-412. (SCI)

138. Tsai, T.H.*, Liu, M.C. (2004) Determination of extracellular hesperidin in blood and bile of anaesthetized rats by microdialysis with high-performance liquid chromatography: a pharmacokinetic application. Journal of Chromatography B. 806:161-166. (SCI)

139. Tseng, T.Y., Tsai, T.H.* (2004) Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence by the acupuncture. Analytica Chimica Acta. 517:47-52. (SCI)

140. Wu, J.W., Shih, H.H., Wang, S.C., Tsai, T.H.* (2004) Determination and pharmacokinetic profile of pyrazinamide in rat blood, brain and bile using microdialysis coupled with high-performance liquid chromatography and verified by tandem mass spectrometry. Analytica Chimica Acta. 522:231-239 (SCI)

141. Tsai, P.L., Tsai, T.H.* (2004) Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. Planta Medica 70:1069-1074 (SCI)

142. Chang, C.H., Fan, K.H., Chen, T.J., Hsu, W.C., Jan, M.L., Tsai, T.H., Kao, P.F., Chen, C.F., Fu, Y.K., Lee, T.W. (2004) Dynamic evaluation of [18F]FDG uptake in fibrosarcoma-bearing mouse model: by microPET and whole body autoradiography. Journal of the Formosan Medical Association. 103:867-881 (SCI)

143. Wang, S.C., Tseng, T.Y., Huang, C.M., Tsai, T.H.* (2004) Gardenia herbal active constituents – Applicable separation procedures. Journal of Chromatography B. 812:193-202. (SCI)

144. Fang, J.Y., Tsai, T.H., Hung, C.F., Wong, W.W. (2004) Development and Evaluation of the Essential Oil from Magnolia fargesii for Enhancing the Transdermal Absorption of Theophylline and (+)-Catechin. Journal of Pharmacy and Pharmacology. 56:1493-500. (SCI)

145. Huang, S.M., Tsai, D.R., Tsai, T.H.* (2005) Measurement of unbound ranitidine in blood and bile of anesthetized rats using microdialysis coupled to liquid chromatography and its pharmacokinetic application. Journal of Chromatography A 1073:297-302 (SCI)

146. Lin, L.C., Yang, K.Y., Chen, Y.F., Wang, S.C., Tsai, T.H.* (2005) Measurement of daphnoretin in plasma of freely moving rat by liquid chromatography. Journal of Chromatography A 1073:285-289 (SCI)

147. Huang, Y.J., Liao, J.F., Tsai, T.H.* (2005) Concurrent determination of thalidomide in rat blood, brain and bile using multiple microdialysis coupled to liquid chromatography. Biomedical Chromatography. 19:488-493 (SCI)

148. Ueng, Y.F., Tsai, T.H., Don, M.J., Chen, R.M., Chen, T.L. (2005) Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa. Journal of Pharmacy and Pharmacology 57:227-232 (SCI)

149. Tsai, T.H.* (2005) Concurrent measurement of unbound genistein in the blood, brain and bile of anesthetized rats using microdialysis and its pharmacokinetic application. Journal of Chromatography A 1073:317-322 (SCI)

150. Chuang, H.N., Wang, J.Y., Chiu, J.H., Tsai, T.H., Yeh, S.F., Fu, S.L., Lui, W.Y., Wu, C.W. (2005) Enhancing Effects of Scutellaria baicalensis and Some of its Constituents on TGF-β1 Gene Expression in RAW 264.7 Murine Macrophage Cell Line. Planta Medica. 71:440-445. (SCI)

151. Chen, Y.F., Chang, C.H., Wang, S.C., Tsai, T.H.* (2005) Measurement of protein-unbound cocaine in blood, brain, and bile of anesthetized rats using microdialysis coupled with liquid chromatography and verified by tandem mass spectrometry. Biomedical Chromatography. 19:402-408. (SCI)

152. Chen, Y.J., Shieh, C.J., Tsai, T.H., Kuo, C.D., Ho, L.T., Liu, T.Y., Liao, H.F. (2005) Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anti-Cancer Drugs. 16:293-299. (SCI)

153. Juan, Y.P., Tsai, T.H.* (2005) Measurement and pharmacokinetics of vincamine in rat blood and brain using microdialysis. Journal of Chromatography A. 1088:146-151. (SCI)

154. Chang, C.H., Tsai, L.C., Chen, S.T., Yuan, C.C., Hung, M.W., Hsieh, B.T., Chao, P.L., Tsai, T.H., Lee, T.W. (2005) Radioimmunotherapy and apoptotic induction on Ck19 overexpressing human cervical carcinoma cells with Re-188-mAbCx-99. Anticancer Research. 25:2719-2728. (SCI)

155. Chang, Y.L., Tsai, P.L., Chou, Y.C., Tien, J.H., Tsai, T.H.* (2005) Simultaneous determination of nicotine and its metabolite, cotinine, in rat blood and brain tissue using microdialysis coupled with HPLC-UV: a pharmacokinetic application. Journal of Chromatography A. 1088:152-157. (SCI)

156. Wang, J.Y., Chiu, J.H., Tsai, T.H., Tsou, A.P., Hu, C.P., Chi, C.W., Yeh, S.F., Lui, W.Y., Wu, C.W., Chou, C.K., (2005) Gene expression profiling predicts liver responses to a herbal remedy after partial hepatectomy in mice. International Journal of Molecular Medicine. 16:221-231. (SCI)

157. Chen, Y.F., Jaw, I., Shiao, M.S., Tsai, T.H.* (2005) Determination and pharmacokinetic analysis of salvianolic acid B in rat blood and bile by microdialysis and liquid chromatography. Journal of Chromatography A. 1088:140-145. (SCI)

158. Tsai, T.H.*, Chang, C.H., Lin, L.C. (2005) Effect of Evodia rutaecarpa on the pharmacokinetics of caffeine. Planta Medica. 71:640-645. (SCI)

159. Tsai, P.L., Tsai, T.H.* (2005) Measurement of unbound pravastatin in rat blood and bile on the perspective of hepatobiliary excretion and its interaction with cyclosporin A and berberine. Analytica Chimica Acta. 548:33-40 (SCI)

160. Hsieh, Y.J., Lin, L.C., Tsai, T.H.* (2005) Identification and determination of plumbagin from the roots of Plumbago zeylanica extract by liquid chromatography with tandem mass spectrometry. Journal of Chromatography A. 1083:141-145. (SCI)

161. Jan, W.C., Lin, L.C., Chou, C.J., Tsai, T.H.* (2005) Herb-drug interaction of Evodia rutaecarpa extract on the pharmacokinetics of theophylline in rats. Journal of Ethnopharmacology. 102:440-445. (SCI)

162. Chen, Y.J., Liao, H.F., Tsai, T.H., Wang, S.Y., Shiao, M.S. (2005) Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. International Journal of Radiation Oncology Biology Physics. 63:1252-1261. (SCI)

163. Chang, C.H., Jan, M.L., Fan, K.H., Wang, H.E., Tsai, T.H., Chen, C.F., Fu, Y.K., Lee, T.W. (2006) Longitudinal Evaluation of Tumor Metastasis by an FDG-microPET/microCT Dual-Imaging Modality in a Lung Carcinoma-Bearing Mouse Model. Anticancer Research. 26:159-166. (SCI)

164. Chang, C.H., Wu, S.Y., Wang, H.E., Fan, K.H., Tsai, T.H., Lee, T.W., Chang, S.R., Liu, R.S., Fu, Y.K. (2006) Comparative evaluation of FET and FDG for differentiating lung carcinoma from inflammation in mice. Anticancer Research. 26:917-926. (SCI)

165. Shyr, M.H., Tsai, T.H., Lin, L.C. (2006) Isolation and Structures of Rossicasin A, B and Rosicaside F, new phenylpropanoid Glycosides from Boschniakia rossica Chemical and Pharmaceutical Bulletin. 54:252-254. (SCI)

166. Wang, S.C., Ho, L.K., Yen, J.C., Chen, Y.F., Tsai, T.H.* (2006) An automated blood sampling system to measure lovastatin level in plasma and feces of freely moving rat and verified by LC-MS/MS. Biomedical Chromatography. 20:911-916. (SCI)

167. Shyr, M.H., Lin, L.C. Lin, T.Y. Lin, Tsai, T.H.* (2006) Determination and pharmacokinetics of evodiamine in the plasma and feces of conscious rats. Analytica Chimica Acta. 558:16-21. (SCI)

168. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2006) Determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometry. Biomedical Chromatography. 20:1076-1081. (SCI)

169. Hsieh, C.L., Cheng, C.Y., Tsai, T.H., Lin, I.H., Liu, C.H., Chiang, S.Y., Lin, J.G., Lao, C.J., Tang, N.Y. (2006) Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. Journal of Ethnopharmacology. 106:208-215. (SCI)

170. Shyr, M.H., Lin, L.C., Chang, C.H., Wu, Y.T., Hsieh, Y.J., Tsai, T.H.* (2006) Hepatobiliary excretion and brain distribution of caffeine in rat using microdialysis. Analytica Chimica Acta. 566:265-270. (SCI)

171. Wang, J.Y., Chuang, H.N., Chiu, J.H., Fu, S.L., Tsai, T.H., Tsou, A.P., Hu, C.P., Chi, C.W., Yeh, S.F., Lui, W.Y., Wu, C.W., Chou, C.K. (2006) Effect of Scutellaria baicalensis Georgi on macrophage hepatocyte interaction through cytokines related to growth control of murine hepatocytes. Experimental Biology and Medicine. 231: 444-455. (SCI)

172. Chiou, S.H., Ku, H.H., Tsai, T.H., Lin, H.L., Chen, L.H., Chien, C.S., Ho, L.L.T., Lee, C.H., Chang, Y.L., (2006) Moclobemide (MB) Up-regulated Bcl-2 Expression and Induced Neural Stem Cell Differentiation into Serotoninergic Neuron via extracellular-regulated kinase (ERK) Pathway. British Journal of Pharmacology. 148:587-598. (SCI)

173. Jan, W.C., Lin, L.C., M.J. Don, Chen, C.F., Tsai, T.H.* (2006) Elimination of rutaecarpine and its metabolites in rat feces and urine measured by liquid chromatography. Biomedical Chromatography. 20:1163-1171. (SCI)

174. Lin, L.C., Tsai, T.H.* (2006) Pharmacokinetics brain distribution of unbound levamisole in the anesthetized rats using microdialysis and microbore column liquid chromatography. Analytica Chimica Acta. 569:145-150. (SCI)

175. Chen, Y.J., Lin, L.C., Shyr, M.H., Tsai, T.H.* (2006) Pharmacokinetics of unbound linezolid in the blood and the mechanism of hepatobiliary excretion in the rat. Analytica Chimica Acta. 570:59-64. (SCI)

176. Lin, L.C., Shen, C.C., Shen, Y.C., Tsai, T.H.* (2006) Anti-inflammatory neolignans from Piper kadsura. Journal of Natural Products. 69:842-844. (SCI)

177. Hsieh, Y.J., Lin, L.C., Tsai, T.H.* (2006) Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry. Journal of Chromatography B. 844:1-5. (SCI)

178. Wu, Y.T., Chen, Y.F., Hsieh, Y.J., Jaw, I., Shiao, M.S., Tsai, T.H.* (2006) Bioavailability of salvianolic acid B in conscious and freely moving rats. International Journal of Pharmaceutics. 326:25-31. (SCI)

179. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2006) Determination of acteoside in Cistanche deserticola and Boschniakia rossica and its pharmacokinetics in freely-moving rats using LC-MS/MS. Journal of Chromatography B. 844:89-95. (SCI)

180. Chen, S.J., Kao, C.L., Chang, Y.L., Yen, C.J., Shui, J.W., Chien, C.S., Chen, I.L., Tsai, T.H., Ku, H.H., Chiou, S.H. (2007) Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through Bcl-2. Current Neurovascular Research. 4:19-29 (SCI)

181. Fang, J.Y., Tsai, T.H., Lin, Y.Y., Wong, W.W., Wang, M.N., Huang, J.F. (2007) Transdermal delivery of tea catechins and theophylline enhanced by terpenes: a mechanistic study. Biological and Pharmaceutical Bulletin. 30: 343-349. (SCI)

182. Lin, L.C., Wang, M.N., Tseng, T.Y., Sung, J.S., Tsai, T.H.* (2007) Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution. Journal of Agriculture and Food Chemistry. 55: 1517-1524. (SCI)

183. Chiou, S.H., Ku, H.H., Chen, M., Huang, Y.L., Tsai, Y.J., Chen, L.S., Chung, C.F., Chiu, J.H., Tsai, T.H.* (2007) Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis. Analytical Biochemistry. 363:46-57. (SCI)

184. Wang, S.C., Huang, C.M., Tsai, T.H. (2007) Determinations of geniposide using LC/MS/MS methods via forming ammonium and acetate adducts. Microchemical Journal. 86:174-182. (SCI)

185. Lin, H.T., Kao, C.L., Lee, K.H., Chang, Y.L., Chiou, S.H., Tsai, F.T., Tsai, T.H., Sheu, D.C., Ho, L.L.T., Ku, H.H. (2007) Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method. World Journal of Gastroenterology. 13:1672-1679.

186. Chang, C.M., Kao, C.L., Chang, Y.L., Yang, M.J., Chen, Y.C., Sung, B.L., Tsai, T.H., Chao, K.C., Chiou, S.H., Ku, H.H. (2007) Placenta-derived multipotent stem cells induced to differentiate into insulin-positive cells. Biochemical and Biophysical Research Communications. 347:414-420 (SCI)

187. Huang, Y.T., Cheng, C.J., Lai, T.F., Tsai, T.R., Tsai, T.H., Chuo, W.H., Cham, T.M. (2007) An investigation of acetylcholine released in skeletal muscle and protein unbound drug released in blood based on the pyridostigmine bromide (pretreatment drug) sustained-release pellets by microdialysis technique in the rabbit model. Neuroscience Letter. 416:302-306. (SCI)

188. Yang, K.Y., Lin, L.C., Tseng, T.Y., Wang, S.C., Tsai, T.H.* (2007) Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. Journal of Chromatography B. 853:183-189. (SCI)

189. Lin, L.C., Chen, Y.F., Tsai, T.R., Tsai, T.H.* (2007) Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat. Analytica Chimica Acta. 590:173-179. (SCI)

190. Wu, Y.T., Tsai, T.R., Lin, L.C., Tsai, T.H.* (2007) Liquid chromatographic method with amperometric detection to determine acteoside in rat blood and brain microdialysates and its application to pharmacokinetic study. Journal of Chromatography B. 853:281-286. (SCI)

191. Chang, Y.L., Chiou, S.H., Chou, Y.C., Yen, C.J., Tsai, T.H.* (2007) Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 45: 158–163. (SCI)

192. Chang, C.H., Hsu, W.C., Wang, C.Y., Jan, M.L., Tsai, T.H., Lee, T.W., Lynn, S.G., Yeh, C.H., Chang, T.J. (2007) Longitudinal microSPECT/CT imaging and Pharmacokinetics of Synthetic Luteinizing Hormone Releasing Hormone (LHRH) vaccine in rats. Anticancer Research. 27:3251-3258. (SCI)

193. Wang, G.J., Tsai, T.H., Lin, L.C. (2007) New Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum. Phytochemistry. 68: 2455–2464. (SCI)

194. Wu, J.W., Tsai, T.H.* (2007) Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid. Drug Metabolism and Disposition. 35:1603-1610. (SCI)

195. Wu, J.W., Lin, L.C., Hung, S.C., Chi, C.W., Tsai, T.H.* (2007) Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. Journal of Pharmaceutical and Biomedical Analysis. 45:635-641. (SCI)

196. Lin, C.L., Lin, S.J., Huang, W.J., Ku, Y.L., Tsai, T.H., Hsu, F.L. (2007) Novel ent-Beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina. Planta Medica. 73: 1581-1587. (SCI)

197. Ho, Y.F., Lai, M.Y., Yu, S.Y., Huang, T.K., Shai, W.C., Tsai, T.H., Lin, C.Y. (2008) Application of rat in situ single-pass intestinal perfusion in the evaluation of pre-systemic extraction of indinavir under different perfusion rates. Journal of the Formosan Medical Association. 107:37–45. (SCI)

198. Peng, C.H., Chiou, S.H., Chen, S.J., Chou, Y.C., Ku, H.H., Cheng, C.K., Yen, C.J., Tsai, T.H., Chang, Y.L., Kao, C.L. (2008) Neuroprotection by imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. European Neuropsychopharmacology. 18:128-140. (SCI)

199. Chen, Y.J., Huang, S.M., Liu, C.Y., Yeh, P.H., Tsai, T.H.* (2008) Hepatobiliary excretion and enterohepatic circulation of colchicine in rats. International Journal of Pharmaceutics. 350:230-239. (SCI)

200. Hsieh, Y.J., Chang, C.H., Huang, S.P., Lin, C.W., Wang, M.N., Wu, Y.T., Chen, Y.J., Tsai, T.H.* (2008) Effects of the cyclosporin A on the brain distribution of doxorubicin in rats. International Journal of Pharmaceutics. 350:265-271. (SCI)

201. Wu, J.W., Lin, L.C., Hung, S.C., Lin, C.H., Chi, C.W., Tsai, T.H.* (2008) Hepatobiliary excretion of silibinin and liver cirrhosis induced by dimethylnitrosamine. Drug Metabolism and Disposition. 36:589-596. (SCI)

202. Tsai, T.H., Wang, G.J., Lin, L.C. (2008) Vasorelaxing alkaloids and flavonoids from Cassytha filiformis. Journal of Natural Products. 71:289-291. (SCI)

203 Fu, Y.S., Lin, Y.Y., Chou, S.C., Tsai, T.H., Kao, L.S., Hsu, S.Y., Cheng, F.C., Shih, Y.H., Cheng, H., Fu, Y.Y., Wang, J.Y. (2008) Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-encitotoxicity – potential therapeutic application for treatment of glioma. Neuro-Oncology. 10:139-152. (SCI)

204. Lee, Y.Y., Kao, C.L., Tsai, P.H., Tsai, T.H., Chiou, S.H., Wu, W.F., Ku, H.H., Wong, T.T. (2008) Caffeic acid phenethyl ester preferentially enhanced radiosensitizing and increased oxidative stress in medulloblastoma cell line. Childs Nervous System. 24:978-994. (SCI)

205. Hsu, C.H., Tsai, T.H., Kao, Y.H., Hwang, K.C., Tseng, T.Y., Chou, P. (2008) Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clinical Nutrition. 27:363-370 (SCI)

206. Kapuriya, N., Kapuriya, K., Zhang, X., Chou, T.C., Kakadiya, R., Wu, Y.T., Tsai, T.H., Chen, Y.T., Lee, T.C., Shah, A., Naliapara, Y., Su, T.L. (2008) Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage. Bioorganic and Medicinal Chemistry. 16:5413-5423. (SCI)

207. Chiou, S.H., Yu, C.C., Huang, C.Y., Lin, S.C., Liu, C.J., Tsai, T.H., Chou, S.H., Chien, C.S., Ku, H.H., Lo, J.F. (2008) Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma. Clinical Cancer Research. 14:4085-4095. (SCI)

208. Lin, L.C., Wang, M.N., Tsai, T.H.* (2008) Herb-drug interaction of (-)-epigallocatechin-3-gallate on the pharmacokinetics of irinotecan and metabolite SN-38. Chemico-Biological Interactions. 174:177-182. (SCI)

209. Tsai, T.H., Lin, L.C. (2008) Phenolic glycosides and pyrrolidium alkaloids from Codonopsis tangshen. Chemical and Pharmaceutical Bulletin. 56:1546-1550. (SCI)

210. Lin, L.C., Chen, Y.F., Lee, W.C., Wu, Y.T., Tsai, T.H.* (2008) Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 48:909-917. (SCI)

211. Wang, S.C., Liao, H.J., Lee, W.C., Huang, C.M., Tsai, T.H. (2008) Using orthogonal array to obtain gradient liquid chromatography conditions of enhanced peak intensity to determine geniposide, genipin with electrospray tandem mass spectrometry. Journal of Chromatography A. 1212:68-75. (SCI)

212. Kapuriya, N., Kapuriya, K., Dong, H., Zhang, X., Chou, T.C., Chen, Y.T., Lee, T.C., Lee, W.C., Tsai, T.H., Naliapara, Y., Su, T.L. (2009) Novel DNA-directed alkylating agents: Design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. Bioorganic and Medicinal Chemistry. 17:1264-1275. (SCI)

213. Huang, T.F., Chen, Y.T., Yang, T.H., Chen, L.L., Chiou, S.H., Tsai, T.H., Tsai, C.C., Chen, M.H., Ma, H.L., Hung, S.C. (2009) Isolation and characterization of mesenchymal stromal cells from human anterior cruciate ligament. Cytotherapy. 10:806-814. (SCI)

214. Wu, J.W., Lin, L.C., Tsai, T.H.* (2009) Drug-drug interactions of silymarin on the perspective of pharmacokinetics. Journal of Ethnopharmacology. 121:185-193. (SCI)

215. Huang, S.P., Lin, L.C., Wu, Y.T., Tsai, T.H.* (2009) Pharmacokinetics of kadsurenone in rats using HPLC and microdialysis system. Journal of Chromatography B. 877:247-252. (SCI)

216. Liu, H.K., Tsai, T.H., Chang, T.T., Chou, C.J., Lin, L.C. (2009) Lanostane-triterpenoids from the fungus Phellinus gilvus. Phytochemistry. 70:558-563. (SCI)

217. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2009) Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection. Journal of Chromatography A. 1216:3501–3507. (SCI)

218. Chang, J.C., Lee, W.C., Lin, L.C., Tsai, T.H.* (2009) Distribution of blood-to-muscle for clenbuterol in rat using microdialysis. International Journal of Pharmaceutics. 372: 91-96.

219. Wu, Y.T., Huang, C.M., Lin, C.C., Ho, W.A., Lin, L.C., Chiu, T.F., Tarng, D.C., Lin, C.H., Tsai, T.H.* (2009) Determination of melamine in rat plasma, liver, kidney, spleen, bladder and brain by liquid chromatography tandem mass spectrometry. Journal of Chromatography A. 1216:7595-7601. (SCI)

220. Wang, G.J., Tsai, T.H., Chang, T.T., Chou, C.J., Lin, L.C. (2009) Lanostanes from Phellinus igniarius and their iNOS inhibitory activities. Planta Medica. 75:1-6. (SCI)

221. Chen, W.L., Tsai, T.H., Huang, C.C., Chen, J.H., Kuo, C.D. (2009) Heart rate variability predicts short-term outcome for successfully resuscitated patients with out-of-hospital cardiac arrest. Resuscitation. 81:1114-1118. (SCI)

222. Ho, Y.F., Huang, D.K., Hsueh, W.C., Lai, M.Y., Yu, H.Y., Tsai, T.H. (2009) Effects of St. John's wort extract on indinavir pharmacokinetics in rats: Differentiation of intestinal and hepatic impacts. Life Sciences 85: 296–302. (SCI)

223. Chang, J.C., Wu, Y.T., Lee, W.C., Lin, L.C., Tsai, T.H.* (2009) Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats. Chemico-Biological Interactions. 182:227-232. (SCI)

224. Hsieh, C.H., Wei, M.C., Lee, H.Y., Hsiao, S.M., Chen, C.A., Wang, L.Y., Hsieh, Y.P., Tsai, T.H., Chen, Y.J., Shueng, P.W. (2009) Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical Tomothearapy. Radiation Oncology. 4:62. (SCI)

225. Chen, C.A., Chang, H.H., Kao, C.Y., Tsai, T.H., Chen, Y.J. (2009) Plumbagin, Isolated from Plumbago zeylanica, Induces Cell Death through Apoptosis in Human Pancreatic Cancer Cells. Pancreatology, 9:797-809. (SCI)

226. Chen, I.L., Tsai, Y.J., Huang, C.M., Tsai, T.H.* (2010) Pharmacokinetics of quercetin in rat plasma and lymph on a mesenteric lymphatic-cannulated model. Journal of Agriculture and Food Chemistry. 58:546-551. (SCI)

227. Wu, Y.T., Huang, C.M., Lin, C.C., Ho, W.A., Lin, L.C., Chiu, T.F., Tarng, D.C., Lin, C.H., Tsai, T.H.* (2010) Oral bioavailability, urinary excretion and organ distribution of melamine in Sprague–Dawley rats by high-performance liquid chromatography with tandem mass spectrometry. Journal of Agriculture and Food Chemistry. 58:108-111. (SCI)

228. Chen, C.C., Tsai, T.H., Huang, Z.R., Fang, J.Y. (2010) Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. European Journal of Pharmaceutics and Biopharmaceutics. 74: 474–482. (SCI)

229. Chen, K.H., Hsu, C.C., Song, W.S., Huang, C.S., Tsai, C.C., Kuo, C.D., Hsu, H.S., Tsai, T.H., Tsai, C.Y., Woung, L.C., Chiou, S.H., Lu, K.H., Chen, Y.W. (2010). Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells. Childs Nervous System. 26:1605-1612. (SCI)

230. Chen, W.L., Tsai, T.H., Yang, C.C.H., Kuo, T.B.J (2010) Acute Effects of Ephedra on Autonomic Nervous Modulation in Healthy Young Adults. Clinical Pharmacological Therapy. 88(1):39-44. (SCI)

231. Chen, W.L., Tsai, T.H., Yang, C.C.H., Kuo, T.B.J. (2010) Effects of ephedra on autonomic nervous modulation in healthy young adults. Journal of Ethnopharmacology. 130:563-568. (SCI)

232. Tsai, Y.J., Lin, L.C., Tsai, T.H.* (2010) Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. Journal of Agriculture and Food Chemistry. 58, 4638–4643. (SCI)

233. Hsieh, C.H., Hsieh, Y.J., Lin, C.Y., Tai, H.C., Huang, Y.C., Shueng, P.W., Lee, H.Y., Tsai, T.H.*, Chen, Y.J.* (2010) Abdominal Irradiation Modulates 5-Fluorouracil Pharmacokinetics. Journal of Translational Medicine. 8:29 (SCI)

234. Lee, W.C., Tsai, T.H.* (2010) Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application. International Journal of Pharmaceutics. 395, 78-83. (SCI)

235. Wu, Y.T., Kao, Y.L., Lin, L.C., Tsai, T.H.* (2010) Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats. International Journal of Pharmaceutics. 396, 127–133. (SCI)

236. Chien, C.F., Wu, Y.T., Lee, W.C., Lin, L.C., Tsai, T.H.* (2010) Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chemico-Biological Interactions. 184: 458-465. (SCI)

237. Tsai, T.H.*, Chen, I.L. (2010) Rebuttal to a comment on lymphatic absorptions of quercetin and rutin in the rat and their pharmacokinetics in systemic plasma. Journal of Agriculture and Food Chemistry. 58, 8468-8469. (SCI)

238. Lin, C.C., Wu, Y.T., Yen, J.C., Chiang, C.J., Tsuang, Y.H., Tsai, T.H.* (2010) In vitro and in vivo models to measure ceftriaxone distribution into the rat tail intervertebral disc. Analytical Sciences. 26, 979-982. (SCI)

239. Tsai, T.H., Liu, Y.C., Lin, L.C. (2010). Flavonoids from Taxillus theifer. Journal of Food and Drug Analysis. 18: 256-262. (SCI)

240. Wu, Y.T., Lin, C.W., Lin, L.C., Chiu, A.W., Chen, K.K., Tsai, T.H.* (2010) Analysis of biliary excretion of icariin in rats. Journal of Agriculture and Food Chemistry. 58(18):9905-9911. (SCI)

241. Wang, K.L., Yang, Y.C., Lai, C.Y.J, Tsai, T.H., Lin, C.P., Wu, Y.T., Chen, Y.Y., Wang, S.C., Chen, Y.J. (2010) Comparison in purity and antitumor effect of brand and generic paclitaxel against human ovarian cancer cells by an in vitro experimental model. Drug Development and Industrial Pharmacy. 36, 1253-1258. (SCI)

242. Wang, C.L., Fan, Y.B., Lu, H.H., Tsai, T.H., Tsai, M.C., Wang, H.P. (2010) Evidence of d-phenylglycine as delivering tool for improving l-dopa absorption. Journal of Biomedical Science. 17(1):71. (SCI)

243. Su, S.Y., Cheng, C.Y., Tsai, T.H., Hsiang, C.Y., Ho, T.Y., Hsieh, C.L. (2010) Paeonol Attenuates H2O2-Induced NF-κB-Associated Amyloid Precursor Protein Expression. The American Journal of Chinese Medicine, 38, 1171-1192. (SCI)

244. Chien, C.F., Wu, Y.T., Tsai, T.H.* (2011) Biological analysis of herbal medicines used for the treatment of liver diseases. Biomedical Chromatography. 25:21-38. (SCI)

245. Lai, J.C.Y., Chen, J.R., Chen, Y.J., Hsu, C.H., Wang, T.Y., Yang, Y.C., Su, T.H., Tsai, T.H., Wang, K.L. (2011) Villoglandular Adenocarcinoma of the Uterine Cervix: An Analysis of 12 Clinical Cases. International Journal of Gerontology 5, 49-52. (SCI)

246. Wei, Y.J., Tsai, K.S., Lin, L.C., Lee, Y.T., Chi, C.W., Tsai, T.H.*, Hung, S.C.* (2011) Catechin stimulates osteogenesis by enhancing PP2A activity in human mesenchymal stem cells. Osteoporosis International. 22: 1469-1479. (SCI)

247. Tsai, Y.M., Jan, W.C., Chien, C.F., Lee, W.C., Lin, L.C., Tsai, T.H.* (2011) Optimized nanoformulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats. Food Chemistry. 127, 918–925. (SCI)

248. Lin, H.C., Yang, Y.Y., Tsai, T.H., Huang, C.M., Huang, Y.T., Lee, F.Y., Liu, T.T., Lee, S.D., (2011) The relationship between endotoxemia and hepatic endocannabinoids in cirrhotic rats with portal hypertension. Journal of Hepatology. 54, 1145-1153. (SCI)

249. Hung, S.H., Yeh, C.K., Tsai, T.H., Chen, T., Chen, R.C. (2011) A simple method for quantifying ultrasound-triggered microbubble destruction. Ultrasound in Medicine and Biology. 37, 949-957. (SCI)

250. Hsu, C.H., Liao Y.L., Lin, S.C., Tsai, T.H., Huang, C.J., Chou, P. (2011) Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double blind, and placebo-controlled clinical trial. Alternative Medicine Review. 16, 157-163. (SCI)

251. Lin, L.C., Tsai, T.H., Su, S.C. (2011). A Novel 8.O.6'-Neolignan from Taxillus theifer. Natural Product Research. 25, 1319-1323. (SCI)

252. Hsieh, C.H., Liu, C.Y., Hsieh, Y.J., Tai, H.C., Wang, L.Y., Tsai, T.H*, Chen, Y.J.*. (2011) Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-fluorouracil. PLoS ONE. 6(6):e21000. (SCI)

253. Tsai, Y.M., Chien, C.F., Lin, L.C., Tsai, T.H.* (2011) Curcumin and its nano-formulation: the kinetics of tissue distribution and blood brain barrier penetration. International Journal of Pharmaceutics. 416, 331-338. (SCI)

254. Yang, J.L., Chen, J.S., Yang, Y.F., Chen, J.C., Lin, C.H., Chang, R.S., Tsao, P.J., Chen, F.P., Chern, C.M., Tsai, T.H., Chiu, J.H. (2011) Neuroprotection effects of retained acupuncture in neurotoxin-induced Parkinson's disease mice. Brain Behavior and Immunity. 25(7):1452-1459. (SCI)

255. Hsieh, C.H., Liao, H.F., Kuo, C.D., Huang, Y.C., Shueng, P.W., Hsu, Y.P., Wang, L.Y., Tsai, T.H.*, Chen, Y.J.* (2011) Norcantharidin Modulates Development of Dendritic Cells and Prolongs Skin Allograft Survival. Transplantation. 92, 848-857. (SCI)

256. Liu, C.Y., Lai, Y.L., Lin, C.P., Wu, Y.T., Tsai, T.H., Chen, Y.J. (2011) Anti-tumor effect of Archidendron lucidum (Benth.) against esophageal cancer, colorectal cancer and hepatoma. Journal of Medicinal Plants Research. 5(21), 5221-5229. (SCI)

257. Wang, S.C., Lee, S.C., Hung, C.H., Liao, H.J., Huang, C.M., Tsai, T.H. (2011) Using orthogonal arrays to obtain efficient and reproducible extraction conditions of geniposide and genipin in Gardenia fruit with liquid chromatography-mass spectrometry determinations. Journal of Food and Drug Analysis. 19(4), 486-494. (SCI)

258. Hsieh, C.H., Huang, Y.C., Tsai, T.H.*, Chen, Y.J.* (2011) Cantharidin modulates development of human monocyte-derived dendritic cells. Toxicology in vitro. 25(8):1740-1747. (SCI)

259. Jeng, M.J., Song, W.J., Chiou, S.Y., Wu, Y.T., Tsai, T.H., Lin, C.C., Yang, C.F., Tsao, P.C., Lee, Y.S. (2012) Efficacy of Intratracheal Instillation of a Meropenem/ Perfluorochemical Suspension in Acute Lung Injury. Pediatric Pulmonology. 47(2):189-98. (SCI)

260. Chang-Liao, W.L., Chien, C.F., Lin, L.C., Tsai, T.H.* (2012) Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats. Journal of Ethnopharmacology. 141: 668-673. (SCI)

261. Fu, P.K., Wu, C.L., Tsai, T.H., Hsieh, C.L. (2012) Anti-inflammatory and anti-coagulative effects of paeonol on LPS-induced acute lung injury in rats. Evidence-based Complementary and Alternative Medicine. 2012:837513. (SCI)

262. Su, S.Y., Cheng, C.Y., Tsai, T.H., Hsieh, C.L. (2012) Paeonol protects memory after ischemic stroke via inhibiting β-secretase and apoptosis. Evidence-based Complementary and Alternative Medicine. 2012:932823. (SCI)

263. Yang, Y.Y., Tsai, T.H., Huang, Y.T., Lee, T.Y., Chan, C.C., Lee, K.C., Lin, H.C., (2012) Hepatic endothelin-1 and endocannabinoids-dependent effects of hyperleptinaemia in nonalcoholic steatohepatitis-cirrhotic rats. Hepatology. 55(5):1540-1550. (SCI)

264. Lee, W.C., Chang, C.H., Huang, C.M., Wu, Y.T., Chen, L.C., Ho, C.L., Chang, T.J., Lee, T.W., Tsai, T.H.* (2012) Correlations between radioactivity and chemotherapeutics of 111In-VNB-Liposome in pharmacokinetics and biodistribution in rats. International Journal of Nanomedicine. 7, 683–692. (SCI)

265. Hsiao, C.Y , Hung, C.Y., Tsai T.H., Chak, K.F. (2012) A study of the wound healing mechanism of a traditional Chinese medicine, Angelica sinensis, using a proteomic approach. Evidence-Based Complementary and Alternative Medicine. 2012:467531. (SCI)

266. Hsiao, C.Y , Tsai T.H., Chak, K.F. (2012) The molecular basis of wound healing processes induced by Lithospermi Radix: a proteomics and biochemical analysis. Evidence-Based Complementary and Alternative Medicine. 2012: 508972. (SCI)

267. Yang, C.P., Wang, H.A., Tsai, T.H., Fan, A., Hsu, C.L., Chen, C.J., Hong, C.J., Chen, Y.M. (2012) Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments. European Neuropsychopharmacology. 22(8):596-606. (SCI)

268. Lin, L.C., Li, S.H., Wu, Y.T., Kuo, K.L., Tsai, T.H.* (2012) Pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat. Journal of Agricultural and Food Chemistry. 60, 1595−1604. (SCI)

269. Shaw, L.H., Tsai, T.H.* (2012) Simultaneous determination and pharmacokinetics of protein unbound aspirin and salicylic acid in rat blood and brain by microdialysis: an application to herbal-drug interaction. Journal of Chromatography B. 895, 31-38. (SCI)

270. Tsai, Y.M., Chang-Liao, W.L., Chien, C.F., Lin, L.C., Tsai, T.H.* (2012) Effects of polymer molecular weight on relative oral bioavailability of curcumin. International Journal of Nanomedicine. 7, 2957-2966. (SCI)

271. Liu, C.Y., Tsai, T.H., Huang, Y.C., Hsieh, H.R., Liao, H.F., Chen, Y.J. (2012) Differential immunomodulating effects of pegylated liposomal doxorubicin nanoparticles on human macrophages. Journal of Nanoscience and Nanotechnology. 12(10):7739-7746. (SCI)

272. Kuo, J.J., Chang, H.H., Tsai, T.H., Lee, T.Y. (2012) Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. International Journal of Molecular Medicine. 30(3):643-649. (SCI)

273. Kuo, J.J., Chang, H.H., Tsai, T.H., Lee, T.Y. (2012) Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. International Journal of Molecular Medicine. 30(3):673-679. (SCI)

274. Yang, Y.Y., Huang, Y.T., Tsai, T.H., Hou, M.C., Lee, F.Y., Lee, S.D., Lin, H.C. (2012) Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH cirrhosis. Clinical Science. 123(12):669-680. (SCI)

275. Tsao, P.C., Jeng, M.J., Soong, W.J., Tsai, T.H., Wu, Y.T., Lee, Y.S., Chiou, S.Y., Chen, S.J., Tang, R.B. (2012) Cranial neurotransmitter alteration in newborn piglets exposed to oxygen. Journal of the Chinese Medical Association 75, 449-453. (SCI)

276. Shaw, L.H., Lin, L.C., Tsai, T.H.* (2012) HPLC–MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats. PLOS ONE. 7(8): e43848. (SCI)

277. Fu, P.K., Yang, C.Y., Tsai, T.H., Hsieh, C.L. (2012) Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation. Phytomedicine. 19, 1206-1215. (SCI)

278. Lin, C.C., Yen, J.C., Wu, Y.T., Lin, L.C., Tsai, T.H.* (2012) Chemical analysis and transplacental transfer of oseltamivir and oseltamivir carboxylic acid in pregnant rats. PLOS ONE. 7(10): e46062. (SCI)

279. Cheng, J.J., Tsai, T.H., Lin, L.C. (2012) New Alkaloids and Cytotoxic Principles from Sinomenium acutum. Planta Med. 78(17):1873-1877. (SCI)

280. Tsai, Y.J., Tsai, T.H.* (2012) Mesenteric lymphatic absorption and the pharmacokinetics of naringin and naringenin in the rat. Journal of Agricultural and Food Chemistry. 60, 12435-12442. (SCI)

281. Wu, Y.T., Wu, M.T., Lin, C.C., Chien, C.F., Tsai, T.H.* (2012) Pharmacokinetic Studies of Chinese Medicinal Herbs Using an Automated Blood Sampling System and Liquid Chromatography-mass Spectrometry. Journal of Traditional and Complementary Medicine. 2, 33-40.

282. Tsai, T.H.* (2013) A Case of Plagiarism. Journal of Traditional and Complementary Medicine. 3, 81.

283. Chang, L.W., Hou, M.L., Tsai, T.H.* (2013) Pharmacokinetics of dibutyl phthalate (DBP) in the rat determined by UPLC-MS/MS. International Journal of Molecular Sciences. 14, 836-849. (SCI)

284. Cheng, S., Lin, L.C., Lin, C.H., Tsai, T.H.* (2013) Comment on Pharmacokinetics and Urine Metabolite Identification of Dehydroevodiamine in the Rat: From Boymia ruticarpa A. Juss to Tetradium ruticarpum (A. Juss) T. G. Hartley. Journal of Agricultural and Food Chemistry. 61(2), 472. (SCI)

285. Chien, S.I., Yen, J.C., Kakadiya, R., Chen, C.H., Lee, T.C., Su, T.L., Tsai, T.H.* (2013) Determination of tissue distribution of potent antitumor agent ureidomustin (BO-1055) by HPLC and its pharmacokinetic application in rats. Journal of Chromatography B. 917-918, 62-70. (SCI)

286. Liu, Y.M., Liu, Y.K., Lan, K.L., Lee, Y.W., Tsai, T.H.*, Chen, Y.J.* (2013) Medicinal fungus Antrodia cinnamomea inhibits growth and cancer stem cell characteristics of hepatocellular carcinoma. Evidence-Based Complementary and Alternative Medicine. 2013:569737. (SCI)

287. Chaniyara, R., Tala, S., Chen, C.W., Zang, X., Kakadiya, R., Lin, L.F., Chen, C.H., Chien, S.I., Chou, T.C., Tsai, T.H., Lee, T.C., Shah, A., Su, T.L. (2013) Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition. Journal of Medicinal Chemistry. 56, 1544−1563. (SCI)

288. Yang, Y.C., Chen, C.N., Wu, C.I., Huang, W.J., Kuo, T.Y., Kuan, M.C., Tsai, T.H., Huang, J.S., Huang, C.Y. (2013) NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats. Evidence-Based Complementary and Alternative Medicine. 2013;2013:514908.

289. Lin, L.C., Tsai, T.H., Kuo, C.L. (2013). Chemical constituents comparison of Codonopsis tangshen, Codonopsis pilosula var. modesta, and Codonopsis pilosula. Natural Product Research. 18:24. (SCI)

290. Huang, W.C., Huang, C.H., Hsu, H.S., Hsieh, C.C., Hsu, W.H., Tsai, T.H., Chen, Y.J. (2013) Intrathoracic goiter in elderly patients. International Journal of Gerontology. 7 (1), pp. 8-12. (SCI)

291. Hou, M.L., Chang, L.W., Chiang, C.J., Tsuang, Y.H., Lin, C.H., Tsai, T.H.* (2013) Pharmacokinetics of di-isononyl phthalate in freely moving rats by UPLC-MS/MS. International Journal of Pharmaceutics. 450(1-2):36-43. (SCI)

292. Tsai, J.J., Kuo, H.C., Lee, K.F., Tsai, T.H.* (2013) Glycyrrhizin Represses Total Parenteral Nutrition Associated Acute Liver Injury in Rats via Endoplasmic Reticulum Stress Suppression. International Journal of Molecular Science. 14, 12563-12580. (SCI)

293. Hsueh, T.Y., Wu, Y.T., Lin, L.C., Chiu, A.W., Lin, C.H., Tsai, T.H.* (2013) Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim extract on the pharmacokinetics of sildenafil in rats. Molecules. 18, 7323-7335. (SCI)

294. Lu, C.M., Hou, M.L., Lin, L.C., Tsai, T.H.* (2013) Chemical and physical methods to analyze a multi-component traditional Chinese herbal prescription using LC-MS/MS, electron microscope and Congo red staining. Evidence-Based Complementary and Alternative Medicine. 2013: 952796. (SCI)

295. Shaw, L.H., Chen, W.M, Tsai, T.H.* (2013) Identification of multiple ingredients for a traditional Chinese medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. Molecules. 18, 11281-11298. (SCI)

296. Hsieh, C.H., Hou, M.L., Chiang, M.H., Tai, H.C., Tien, H.J., Wang, L.Y., Tsai, T.H.*, Chen, Y.J.* (2013) Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin. Journal of Translational Medicine. 11:231. (SCI)

297. Chang-Liao, W.L., Hou, M.L., Chang, L.W., Lee, C.J., Tsai, Y.M., Lin, L.C., Tsai, T.H.* (2013) Determination and pharmacokinetics of di-(2-ethylhexyl) phthalate in rats by ultra performance liquid chromatography with tandem mass spectrometry. Molecules. 18, 11452-11466. (SCI)

298. Huang, H.L., Yang, W.Y., Pu, H.F., Tsai, T.H., Lin, C.H., Chen, N.J., Tarng, D.C. (2013) Kruppel-like factor 5 associates with melamine-cyanurate crystal-induced nephritis in rats. Nephrology Dialysis Transplantation. 28(10):2477-2483. (SCI)

299. Wu, M.T., Shaw, L.H., Wu, Y.T., Tsai, T.H.* (2013) Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats. Evidence-Based Complementary and Alternative Medicine. 2013: 670858. (SCI)

300. Chen, Y.J., Huang, Y.C., Tsai, T.H.*, Liao, H.F.* (2014) Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2014: 494739. (SCI)

301. Tsai, W.J., Shen, C.C., Tsai, T.H., Lin, L.C. (2014) Lignans from the Aerial Parts of Saururus chinensis: Isolation, Structural Characterization, and Their Effects on Platelet Aggregation. Journal of Natural Products. 77, 125-131. (SCI)

302. Wu, Y.T., Lin, L.C., Tsai, T.H.* (2014) Determination of rhynchophylline and hirsutine in rat plasma by UPLC-MS/MS after oral administration of Uncaria rhynchophylla extract. Biomedical Chromatography. 28: 439–445. (SCI)

303. Tala, S.D., Ou, T.H., Lin, Y.W., Tala, K.S., Chao, S.H., Wu, M.H., Tsai, T.H., Kakadiya, R., Suman, S., Chen, C.H., Lee, T.C., Su, T.L. (2014) Design and synthesis of potent antitumor water-soluble phenyl N-mustard-benzenealkylamide conjugates via a bioisostere approach. European Journal of Medicinal Chemistry 76, 155-169. (SCI)

304. Hou, M.L., Chang, L.W., Lin, C.H., Lin, L.C., Tsai, T.H.* (2014) Determination of bioactive components in Chinese herbal formulae and pharmacokinetics of rhein in rats by UPLC-MS/MS. Molecules. 19(4), 4058-4075. (SCI)

305. Lee, C.J., Wu, Y.T., Hsueh, T.Y., Lin, L.C., Tsai, T.H.* (2014) Pharmacokinetics and oral bioavailability of epimedin C after oral administration of epimedin C and Herba Epimedii extract in rats. Biomedical Chromatography. 28: 630-636. (SCI)

306. Cheng, S., Lin, L.C., Lin, C.H., Tsai, T.H.* (2014) Comparative Oral Bioavailability of Geniposide Following Oral Administration of Geniposide, Gardenia jasminoides Ellis Fruits Extracts and Gardenia Herbal Formulation in Rats. Journal of Pharmacy and Pharmacology. 66, 705-712. (SCI)

307. Lee, C.J., Hsueh, T.Y., Lin, L.C., Tsai, T.H.* (2014) Determination of protein-unbound rhynchiphylline brain distribution by microdialysis and ultra-performance liquid chromatography with tandem mass spectrometry. Biomedical Chromatography. 28(6):901-906. (SCI)

308. Lu, C.M., Hou, M.L., Lin, L.C., Tsai, T.H.* (2014) Development of a microdialysis system to monitor lamivudine in blood and liver for the pharmacokinetic application in herbal drug interaction and the gene expression in rats. Journal of Pharmaceutical and Biomedical Analysis. 96, 231-240. (SCI)

309. Kuo, Y.J., Sun, J.S., Rau, G., Chen, C.H., Tsai, T.H., Tsuang, Y.H. (2014) Better Osteoporotic Fracture Healing with Sintered Dicalcium Pyrophosphate (SDCP) Treatment: A Rat Femur Fracture Model. Journal of Histochemistry & Cytochemistry. 62(8):565-576. (SCI).

310. Cheng, Y.H., Hung, K.H., Tsai, T.H., Lee, C.J., Ku, R.Y., Chiu, A.W., Chiou, S.H., Liu, C.J. (2014) Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension. Acta Biomaterialia. 2014 Oct;10(10):4360-4366.

311. Hou, M.L., Chang, L.W., Lin, C.H., Lin, L.C., Tsai, T.H.* (2014) Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes. Journal of Ethnopharmacology. 155(2), 1291-1299. (SCI).

312. Chen, J.H., Kuo, H.C., Lee, K.F., Tsai, T.H.* (2014) Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine. Toxicology and Applied Pharmacology. 279(3):294-302. (SCI).

313. Ho, J.K., Huo, T.I., Lin, L.C., Tsai, T.H.* (2014) Pharmacokinetics of ractopamine and its organ distribution in rats. Journal of Agricultural and Food Chemistry. 62(38):9273-9278. (SCI).

314. Chang, L.W., Hou, M.L. Hou, Tsai, T.H.* (2014) Silymarin in Liposomes and Ethosomes: Pharmacokinetics and Tissue Distribution in Free-Moving Rats by High-Performance Liquid Chromatography–Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry. 62 (48), 11657–11665. (SCI).

315. Lu, C.M., Lin, L.C., Tsai, T.H.* (2014) Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules. 19(12): 21560-21578. (SCI)

316. Lin, S.I., Tsai, T.H., Chou, Y.J., Huang, N. (2015) Characteristics Associated with Utilization of Asthma-Related Traditional Chinese Medicine Services among Asthma Children in Taiwan: A Nationwide Cohort Study. Evidence-Based Complementary and Alternative Medicine. 2015: 108961. (SCI)

317. Ting, C.T., Li, W.C., Chen, C.Y., Tsai, T.H.* (2015) Preventive and therapeutic role of traditional Chinese herbal medicine in hepatocellular carcinoma. Journal of the Chinese Medical Association. 78 (3): 139-144. (SCI).

318. Lin, L.C., Pai, Y.F., Tsai, T.H.* (2015) Isolation of luteolin and luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and their pharmacokinetics in rats. Journal of Agricultural and Food Chemistry. 63, 7700-7706. (SCI)

319. Chiang, M.H., Chang, L.W., Wang, J.W., Lin, L.C., Tsai, T.H.* (2015) Herb-drug pharmacokinetic interaction of a traditional Chinese medicine Jia-Wei-Xiao-Yao-San with 5-fluorouracil in the blood and brain of rat using microdialysis. Evidence-Based Complementary and Alternative Medicine. Volume 2015, Article ID 729679, 11 pages (SCI)

320. Tsai, T.H. Chen, Y.J. Chen, Hou, M.L., Wang, L.Y., Tai, H.C., Hsieh, C.H. (2015) Pelvic irradiation modulates the pharmacokinetics of cisplatin in the plasma and lymphatic system. American Journal of Translational Research.  7(2):375-384. (SCI).

321. Chang, L.W., Hou, M.L., Hung, S.H., Lin, L.C., Tsai, T.H.* (2015) The pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging. International Journal of Nanomedicine. 10: 3031–3042. (SCI)

322. Hsieh, C.H., Hou, M.L., Wang, L.Y., Tai, H.C., Tsai, T.H.* Chen, Y.J.* (2015) Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System. BMC Cancer. 15:316. (SCI).

323. Chang, C.H., Liu, S.Y., Chi, C.W., Yu, H.L., Chang, T.J., Tsai, T.H., Lee, T.W., Chen, Y.J. (2015) External beam radiotherapy synergizes 188Re-liposome against human esophageal cancer xenograft and modulates 188Re-liposome pharmacokinetics. International Journal of Nanomedicine, 10:3641-3649. (SCI).

324. Chang, L.W., Hou, M.L., Lin, L.C., Tsai, T.H.* (2015) Healthy supplements of silymarin and aqueous extract of Salvia miltiorrhiza on the pharmacokinetic interaction of lamivudine in rats. Journal of Functional Food. 17, 163–171. (SCI)

325. Chen, J.H., Kuo, H.C., Lee, K.F., Tsai, T.H.* (2015) Global Proteomic Analysis of Brain Tissues in Transient Ischemia Brain Damage in Rats. International Journal of Molecular Sciences. 16, 11873-11891. (SCI).

326. Lai, K.M., Cheng, Y.Y., Tsai, T.H.* (2015) The integrated analytical systems of LC-MS/MS and physical inspection for the analysis of a botanical herbal preparation. Molecules. 20(6), 10641-10656. (SCI)

327. Chen, C.H., Chiang, C.J., Wu, L.C., Yang, C.H., Kuo, Y.J., Tsai, T.H.* (2015) In vitro penetration and in vivo Distribution of Honokiol into the Intervertebral disc in Rat. Analytical Sciences. 31, 1297-1302. (SCI)

328. Tsai, J.J., Kuo, H.C., Lee, K.F., Tsai, T.H.* (2015) Proteomic analysis of plasma from rats following total parenteral nutrition-induced liver injury. Proteomics. 15, 3865-3874. (SCI)

329. Hou, M.L., Lin, C.H., Lin, L.C., Tsai, T.H.* (2015) The drug-drug effects of rhein on the pharmacokinetics and pharmacodynamics of clozapine in rat brain extracellular fluid by in vivo microdialysis. Journal of Pharmacology and Experimental Therapeutics. 355, 125-134. (SCI)

330. Hung, S.C., Kuo, K.L., Huang, H.L., Lin, C.C., Tsai, T.H., Wang, C.H., Chen, J.W., Lin, S.J., Huang, P.H., Tarng, D.C. (2016)Indoxyl sulfate suppresses endothelial progenitor cell-mediated neovascularization. Kidney International. 89(3), 574-585.

331. Wang, J.W., Chiang, M.H., Lu, C.M., Tsai, T.H.* (2016) Determination the active compounds of herbal preparation by UHPLC-MS/MS and its application on the preclinical pharmacokinetics of pure compound ephedrine, single herbal extract of Ephedra, and a multiple herbal preparation in rats. Journal of Chromatography B. 1026, 152-161. (SCI)

332. Hsueh, T.Y., Ho, J.K., Lin, L.C., Chiu, A.W., Lin, C.H., Tsai, T.H.* (2016) Herb-drug interaction of Epimedium extract on the pharmacokinetic of dapoxetine in rat. Journal of Chromatography B. 1014, 64-69. (SCI)

333. Hou, M.L., Lu, C.M., Tsai, T.H.* (2016) The herb-drug interaction effects of Jia-Wei-Xiao-Yao-San on the peripheral and lymphatic pharmacokinetics of paclitaxel in rats. Evidence-Based Complementary and Alternative Medicine. Article ID 5614747, 10 pages. (SCI)

334. Hou, M.L., Lu, C.M., Lin, C.H., Lin, L.C., Tsai, T.H.* (2016) Pharmacokinetics of maleic acid as a food adulterant determined by microdialysis in rat blood and kidney cortex. Molecules. 21(3), 367, 1-12. (SCI)

335. Cheng, Y.Y., Tsai, T.H.* (2016) A validated LC-MS/MS determination method for the illegal food additive rhodamine B: Applications of a pharmacokinetic study in rats. Journal of Pharmaceutical and Biomedical Analysis. 125, 394-399. (SCI)

336. Lee, Y.L., Li, W.C., Tsai, T.H., Chiang, H.Y., Ting, C.T. (2016) Body Mass Index and Cholesterol Level Predict Surgical Outcome in Patients with Hepatocellular Carcinoma in Taiwan - a Cohort Study. Oncotarget. 7(16), 22948-22959. (SCI)

337. Huang, W.C., Chan, M.L., Chen, M.J., Tsai, T.H.*, Chen, Y.J.* (2016) Modulation of Macrophage Polarization and Lung Cancer Cell Stemness by MUC1 and Development of a Related Small-Molecule Inhibitor Pterostilbene. Oncotarget. 7(26), 39363-39375. (SCI)

338. Wu, H.T., Wu, H.K., Wang, C.L., Tang, Y.L., Wu, W.H., Tsai, T.H., Chang, H.H. (2016) Modeling the Pulse Signal by Wave-Shape Function and Analyzing by Synchrosqueezing Transform. Plos One. 0157135, 1-20. (SCI)

339. Chen, C.W., Wu, M.H., Chen, Y.F., Yen, T.Y., Lin, Y.W., Chao, S.H., Tala, S., Tsai, T.H., Su, T.L., Lee, T.C. (2016) A Potent Derivative of Indolizino[6,7-b] Indole for Treatment of Human Non-Small Cell Lung Cancer Cells. Neoplasia. 18(4):199-212. (SCI)

340. Chen, C.H., Chiang, C.J., Wu, L.C., Yang, C.H., Kuo, Y.J., Tsuang, Y.H., Tsai, T.H.* (2016) Time Course Investigation of Intervertebral Disc Degeneration in a Rat-tail Puncture Model. Life Sciences. 156, 15-20. (SCI)

341. Cheng, Y.Y., Tsai, T.H.* (2016) Analysis of a ginseng containing multiple components traditional Chinese herbal medicine, Sheng-Mai-San, using liquid chromatography tandem mass spectrometry and physical examination by electron and light microscopies. Molecules. 21, 1159, 1-16. (SCI)

342. Chen, S.T., Lee, T.Y., Tsai, T.H., Lin, Y.C., Lin, C.P., Shieh, H.R., Hsu, M.L., Chi, C.W., Lee, M.C., Chang, H.H., Chen, Y.J. (2016) The Traditional Chinese Medicine DangguiBuxue Tang Sensitizes Colorectal Cancer Cells to Chemoradiotherapy. Molecules. 21, 1677, 1-16. (SCI)

343. Li, T.H., Lee, P.C., Lee, K.C., Hsieh, Y.C., Tsai, C.Y., Yang, Y.Y., Huang, S.F., Tsai, T.H., Hsieh, S.L., Hou, M.C., Lin, H.C., Lee, S.D. (2016) Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis. Scientific Reports. 2016 Dec 23;6:39405. 1-14. (SCI)

344. Chiou, C.T., Shen, C.C., Tsai, T.H., Chen, Y.J., Lin, L.C. (2016) Meroterpenoids and Chalcone-Lignoids from the Roots of Mimosa diplotricha. Journal of Natural Products. 2016 Oct 28;79(10):2439-2445. (SCI)

345. Liao, W.Y., Tsai, T.H., Ho, T.Y., Lin, Y.W., Cheng, C.Y., Hsieh, C.L. (2016) Neuroprotective Effect of Paeonol Mediates Anti-Inflammation via Suppressing Toll-Like Receptor 2 and Toll-Like Receptor 4 Signaling Pathways in Cerebral Ischemia-Reperfusion Injured Rats. Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 3704647, 1-12. (SCI)

346. Liu, Y.M., Liu, Y.K., Wang, L.W., Huang, Y.C., Huang, P.I., Tsai, T.H.*, Chen, Y.J.* (2016) The medicinal fungus Antrodia cinnamomea regulates DNA repair and enhances the radiosensitivity of human esophageal cancer cells. OncoTargets and Therapy. 2016 Oct 27;9:6651-6661. (SCI)

347. Hsueh, T.P., Lin, W.L., Tsai, T.H.* (2016) Using Light Microscopy and Liquid Chromatography Tandem Mass Spectrometry for Qualitative and Quantitative Control of a Combined Three-Herb Formulation in Different Preparations. Molecules. 2016 Dec 6;21(12). pii: E1673. (SCI)

348. Wu, H.K., Ko, Y.S., Lin, Y.S., Wu, H.T., Tsai, T.H.*, Chang, H.H.* (2017) The correlation between pulse diagnosis and constitution identification in traditional Chinese medicine. Complementary Therapies In Medicine. 30: Feb 107-112. (SCI)

349. Ting, C.T., Kuo, C.J., Hu, H.Y., Lee, Y.L.*, Tsai, T.H.* (2017) Prescription Frequency and Patterns of Chinese Herbal Medicine for Liver Cancer Patients in Taiwan: a cross-sectional analysis of the National Health Insurance Research Database. BMC Complementary and Alternative Medicine. 17: 118. (SCI)

350. Su, N.W., Wu, S.H., Chi, C.W., Liu, C.J., Tsai, T.H.,* Chen, Y.J.* (2017) Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition. Molecules. 22(4): E629. doi: 10.3390/molecules22040629. (SCI)

351. Hsueh, T.P., Lin, W.L., Tsai, T.H.* (2017) Pharmacokinetic interactions of herbal medicines for the treatment of chronic hepatitis. Journal of Food and Drug Analysis. 25: 209-218.

352. Cheng, Y.Y., Tsai, T.H.* (2017) Pharmacokinetics and Biodistribution of the Illegal Food Colorant Rhodamine B in Rats. Journal of Agricultural and Food Chemistry. Feb 8; 65(5):1078-1085. (SCI)

353. Huang, J.T., Cheng, Y.Y., Lin, L.C., Tsai, T.H.* (2017) Structural pharmacokinetics of polymethoxylated flavones in rat plasma using HPLC-MS/MS. Journal of Agricultural and Food Chemistry. Mar 22; 65 (11): 2406-2413. (SCI)

354. Ting, C.T., Cheng, Y.Y., Tsai, T.H.* (2017) Herb-drug interaction between the traditional hepatoprotective formulation and sorafenib on hepatotoxicity, histopathology and pharmacokinetics in rats. Molecules. 2017, Jun 22; 22(7). pii: E1034. doi:10.3390/molecules22071034. (SCI)

355. Chen, S.T., Lee, T.Y., Tsai, T.H., Huang, Y.C., Lin, Y.C., Lin, C.P, Shieh, H.R, Hsu, M.L, Chi, C.W, Lee, M.C., Chang, H.H., Chen, Y.J. (2017) Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. Oncotarget. 2017 Aug 3; 8(51):88563-88574. (SCI)

356. Jiang, S.H., Cheng, Y.Y., Huo, T.I., Tsai, T.H.* (2017) Pharmacokinetics of Rhodamine 110 and Its Organ Distribution in Rats. Journal of Agricultural and Food Chemistry. 2017 Sep 6;65(35):7797-7804. (SCI)

357. Chen, Y.J., Tsai, T.H., Wang, L.Y., Hsieh, C.H. (2017) Local Radiotherapy Affects Drug Pharmacokinetics—Exploration of a Neglected but Significant Uncertainty of Cancer Therapy. Technology in Cancer Research & Treatment. Dec;16(6):705-716. (SCI)

358. Liu, J.H., Cheng, Y.Y., Hsieh, C.H., Tsai, T.H.* (2017) Identification of a Multicomponent Traditional Herbal Medicine by HPLC–MS and Electron and Light Microscopy. Molecules. 22(12). pii: E2242. doi: 10.3390/molecules 22122242. (SCI)

359. Liu, J.H., Cheng, Y.Y., Hsieh, C.H., Tsai, T.H.* (2018) The Herb–Drug Pharmacokinetic Interaction of 5-Fluorouracil and Its Metabolite 5-Fluoro-5,6-Dihydrouracil with a Traditional Chinese Medicine in Rats. International Journal of Molecular Sciences. 19(1), 25. pii: E25. doi: 10.3390/ijms19010025. (SCI)

360. Li, C.L., Cheng, Y.Y., Hsieh, C.H., Tsai, T.H.* (2018) Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method. Molecules. 23(1). 173; doi:10.3390/molecules23010173. (SCI)

361. Huang, W.C., Kuo, K.T., Adebayo, B.O., Wang, C.H., Chen, Y.J., Jin, K., Tsai, T.H.*, Yeh, C.T.* (2018) Garcinol inhibits cancer stem cell-like phenotype via suppression of the Wnt/β-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas. Journal of Nutritional Biochemistry. 54:140-150. (SCI)

362. Cheng, Y.Y., Hsieh, C.H., Tsai, T.H.* (2018) Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics. Journal of Food and Drug Analysis. Apr;26(2S):S88-S95. (SCI)

363. Chang, C.W., Liu, C.Y., Lee, H.C., Huang, Y.H., Lee, L.H., Chiau, J.S.C., Wang, T.E., Chu, C.H., Shih, S.C., Tsai, T.H.*, Chen, Y.J.* (2018) Lactobacillus casei Variety rhamnosus Probiotic Preventively Attenuates 5-Fluorouracil/ Oxaliplatin- Induced Intestinal Injury in a Syngeneic Colorectal Cancer Model. Frontiers in Microbiology. 9:983 doi: 10.3389/fmicb.2018.00983 (SCI).

364. Liu, Y.M., Liu, Y.K., Huang, P.I., Tsai, T.H.*, Chen, Y.J.* (2018) Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells. Food Chem Toxicol. 119, Sep. 380-386. (SCI)

365. Huang, A.C., Yeh, K.Y., Cheng, Y.Y., Dubey, N.K., Chiu, A.W., Tsai, T.H.* (2018) Investigation of Interactive Activity of Electro-Acupuncture on Pharmacokinetics of Sildenafil and Their Synergistic Effect on Penile Blood Flow in Rats. International Journal of Molecular Sciences. 19, 2153; doi:10.3390/ijms19082153. (SCI)

366. Huang, M.C., Hsueh, T.Y., Cheng, Y.Y., Lin, L.C., Tsai, T.H.* (2018) Pharmacokinetics and Biliary Excretion of Fisetin in Rats. Journal of Agricultural and Food Chemistry. 66, Jun 6300-6307. (SCI)

367. Hsueh, T.P., Tsai, T.H.* (2018) Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method. Molecules. 23, Oct 22;23(10). pii: E2716. (SCI)

368. Hsueh, T.P., Hsieh, C.H., Tsai, T.H.* (2018) Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics. Journal of Food and Drug Analysis 26, S88-S95. (SCI)

369. Huang, A.C., Wu, J.M., Chang, Y.H., Dubey, N.K., Chiu, A.W., Yeh, C.Y., Tsai, T.H.*, Yeh, K.Y.* (2019 April) Neuronal nitric oxide synthase activity mediates Lycium barbarum polysaccharides-enhanced sexual performance without stimulating noncontact erection in rats. Psychopharmacology. 236, (4), 1293–1301. (SCI)

370. Su, N.W., Wu, S.H., Chi, C.W., Tsai, T.H.*, Chen, Y.J.* (2019) Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair. Food Chem Toxicol. 2019 Feb;124:400-410. doi: 10.1016/j.fct.2018.12.025. (SCI)

371. Li, C.L., Tsuang, Y.H., Tsai, T.H.* (2019 July) Neuroprotective effect of Schisandra chinensis on methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian syndrome in C57BL/6 mice. Nutrients. 11, 1671; doi:10.3390/nu11071671. (SCI)

372. Yang, Y.Y., Tsai, T.H.* (2019 Nov) Enterohepatic circulation and pharmacokinetics of genistin and genistein in rats. ACS Omega. 4, 18428−18433. (SCI)

273. Liao, S.C., Hsu, W.H., Huang, Z.Y., Chuang, K.L., Lin, K.T., Tseng, C.L., Tsai, T.H., Dao, A.H., Su, C.L., Huang, C.F. (2019) Bioactivity Evaluation of a Novel Formulated Curcumin. Nutrients. 2019 Dec 6;11(12). pii: E2982. doi: 10.3390/nu11122982. (SCI)

374. Yang, L., Li, C.L., Cheng, Y.Y., Tsai, T.H.* (2019) Development of a validated UPLC-MS/MS method for rapid analysis of major ginseng saponins from various ginseng species. Molecules. 24, 4065. doi:10.3390/molecules24224065. (SCI)

375. Chang, C.W., Lee, H.C., Li, L.H., Chiang Chiau, J.S., Wang, T.E., Chuang, W.H., Chen, M.J., Wang, H.Y., Shih, S.C., Liu, C.Y., Tsai, T.H.*, Chen, Y.J.* (2020) Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. International Journal of Molecular Science. 2020 Jan 8;21(2). pii: E386. doi: 10.3390/ijms21020386. (SCI)

376. Li, C.L., Hsieh, C.H., Tsai, T.H.* (2020) Preclinical Pharmacokinetics of Lamivudine and Its Interaction with Schisandra chinensis Extract in Rats. ACS Omega 2020, Jan 22; 5(4), 1997−2004. (SCI)

377. Yang, L., Li, C.L., Tsai, T.H.* (2020) Preclinical herb-drug pharmacokinetic interaction of Panax ginseng extract and selegiline in freely moving rats. ACS Omega 2020, Feb 21; 5(9), 4682−4688. (SCI)

378. Liu, J.H., Tsai, T.H., Chen, Y.J., Wang, L.Y., Liu, H.Y., Hsieh, C.H. (2020) Local Irradiation Modulates the Pharmacokinetics of Metabolites in 5-Fluorouracil- Radiotherapy-Pharmacokinetics Phenomenon. Frontiers in Pharmacology. 2020, Feb 27; 11, 141. doi: 10.3389/fphar.2020.00141 (SCI)

379. Hsieh, C.H., Chen, Y.J., Tsai, T.H., Wang, L.Y., Tai, H.C., Huang, H.L., Huang, Y.C. (2020) Robust combination of liver stereotactic body radiotherapy modulates pharmacokinetics of sorafenib toward preferable parameters. Scientific Reports, June 12; 10:9575. doi.org/10.1038/s41598-020-66583-9 (SCI)

380. Peng, W.Y., Tsai, T.H.* (2020) Scanning Electron Microscopy and Liquid Chromatography for Physical and Chemical Inspection of Industrial Pharmaceutical Traditional Chinese Herbal Medicine. ACS Omega 2020, May 11; 5, 11563−11569. (SCI)

381. Hsueh, T.P., Tsai, T.H.* (2020) Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone. BMC Complementary Medicine and Therapies. 20(1):253. Aug. 15, DOI : 10.1186/s12906-020-03042-y.

382. Huang, A.C., Liu, M.C., Tsai, T.H., Chang, Y.H., Wu, J.M., Yeh, K.Y.* (2020) Low‑Frequency Electroacupuncture at Acupoints Guanyuan (CV4) and Zhongji (CV3) Lengthen Ejaculatory Latency and Improves Sexual Behavior in Male Rats. Chinese Journal of Physiology. 63(4):163-170. Aug. 28, DOI : 10.4103/CJP.CJP_34_20. (SCI)

383. Yang, Y.N., Tsai, T.H.* (2020) Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats. Drug Metabolism and Disposition, 48:886–893. October. doi: 10.1124/dmd.120.000088. (SCI)

384. Sun, C.K., C.J., Lin, Y.W., Lin, F.H., Tsai, T.H.*, Sun, J.S.* (2021) Transglutaminase Cross-Linked Gelatin-Alginate-Antibacterial Hydrogel as the Drug Delivery-Coatings for Implant-Related Infections. Polymers, 13, 414. (SCI)

385. Yang, C.N., Peng, W.Y., Lin, L.C., Tsai, T.H.* (2021) Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis. Journal of Ethnopharmacology, 269: 113764. (SCI)

386. Ting, C.T., Cheng, Y.Y., Tsai, T.H.* (2021) Preclinical pharmacokinetic interaction and histopathological analyses of Hedyotis diffusa on sorafenib in rats. ACS Omega. 6(4), 3060−3067. (SCI)

387. Liu, J.H., Hsieh, C.H.*, Liu, C.Y., Chang, C.W., Chen, Y.J., Tsai, T.H.* (2021) Anti-inflammatory effects of Radix aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice. Journal of Ethnopharmacology. 271: 113912. (SCI)

388. Tsai, T.H., Chen, Y.J., Wang, L.Y., Hsieh, C.H.* (2021) Effect of Synchronous Versus Sequential Regimens on the Pharmacokinetics and Biodistribution of Regorafenib with Irradiation. Pharmaceutics. 2021, 13, 386. (SCI)(SCI)

389. Tsai, T.H., Chen, Y.J., Wang, L.Y., Hsieh, C.H.* (2021) Impact of Local Liver Irradiation Concurrent Versus Sequential with Lenvatinib on Pharmacokinetics and Biodistribution. Cancers. 2021, 13, 1598. (SCI)

390. Chiang, Y.H., Wu, Y.T., Lin, L.C., Tsai, T.H.* (2021) Comparative biotransformation of luteolin and apigenin from the flower extract and the stem-and-leaf extract of Dendranthema morifolium Ramat. Tzvel. in rats. Journal of the Science of Food and Agriculture. 2021 Feb 4. doi: 10.1002/jsfa.11137. (SCI)

*Corresponding Author

BOOK EDITOR

  1. Tsai, T.H. (2011) Editor, Applications of microdialysis in pharmaceutical science. John Wiley & Sons, Inc.

BOOK CHAPTERS

  1. Wu, Y.T., Tsai, T.H. (2006) Microdialysis coupled to mass spectrometry: principles and applications, In Wilfried M.A. Nissen (Editor) The encyclopedia of mass spectrometry. Elsevier, pp.352-359.
  2. Tsai, T.H. (2007) Assaying protein-unbound drugs using microdialysis techniques, In Ben H.C. Westerink, Thomas, I.F.H. Cremers (Editors) Handbook of microdialysis, methods, applications and clinical aspects. Elsevier, pp. 573-587.
  3. Wu, J.W., Tsai, T.H. (2008) Absorption, distribution, metabolism and excretion of caffeine, In Frank Columbus (Editor) Caffeine and Health Research. Nova Science Publishers, Inc., Chapter VI, pp. 161-170.
  4. Tsai, T.H. (2011) Introduction to applications of microdialysis in pharmaceutical science, In Tung-Hu Tsai (Editor) applications of microdialysis in pharmaceutical science. John Wiley & Sons, Inc., pp. 1-6.
  5. Wu, Y.T., Tsai, T.H. (2011) Microdialysis in the hepatobiliary system: monitoring drug metabolism, hepatobiliary excretion, and enterohepatic circulation, In Tung-Hu Tsai (Editor) applications of microdialysis in pharmaceutical science. John Wiley & Sons, Inc., pp. 275-294.
  6. Lee, W.C., Tsai, T.H. (2011) In vitro applications of microdialysis, In Tung-Hu Tsai (Editor) applications of microdialysis in pharmaceutical science. John Wiley & Sons, Inc., pp. 445-465.

PATENTS

  1. 中華民國專利證書。新型第M 476577號。新型名稱:微透析探針。專利權人:國立陽明大學。新型創作人:蔡東湖、江孟萱。專利權期間:自2014年4月21日至2023年11月11日。
  2. 中華民國專利證書。新型第M 476578號。新型名稱:多岔型微透析探針。專利權人:國立陽明大學。新型創作人:蔡東湖、張杏怡。專利權期間:自2014年4月21日至2023年11月11日。
  3. 中華人民共和國,實用新型專利證書。證書號第3596588號。實用新型名稱:並聯式微透析管結構體。發明人:謝硯如、蔡東湖、陳昌陽。專利號: ZL 2013 2 0814836.6號。專利權人:財團法人生物技術開發中心。專利權期間:自2014年6月4日至2024年6月3日。

 

歷年研究計畫:

  1. MOST107-2113-M-010-005  建立高效液相串聯質譜分析方法用於食用非法著色劑之食安與藥物動力學評估  科技部  主持人  2018/08/01~2019/07/31 
  2. MOST106-2113-M-010-002  開發中西化療藥物的分析方法並應用於藥物交互作用及可能藥理機轉探討  科技部  主持人  2017/08/01~2018/07/31 
  3. MOST105-2113-M-010-004  開發液相層析串聯質譜方法分析生物檢體中西洋蔘成分應用在藥物動力學及延緩腦部功能性退化之藥效學  科技部  主持人  2016/08/01~2017/07/31
  4. MOST102-2113-M-010-001-MY3  開發高效液相層析串聯質譜法探討三黃瀉心湯於大鼠體內之藥動學和藥效學研究(3/3)  科技部  主持人  2013/08/01~2016/07/31 

本研究室近年來的研究方向主要為開發新型分析方法、建立微透析取樣技術、開發微透析與串聯質譜連線分析技術、藥物動力學及神經藥理學等等。研發與設計微透析取樣技術,藉由設計不同形式的微透析探針,可以進行生物體各部位無體液流失的取樣。另外,本實驗室之研究團隊也致力於藥物分析方法的開發,即利用高效液相層析法(HPLC)結合不同的檢測方式,例如:質譜儀(mass spectrometer)、電化學偵測(electrochemical detection)、螢光偵測(fluorescence detector)與紫外光偵測(UV detection),進行生物樣品內微量藥物之定量分析,進而應用於中草藥、臨床用藥與食品科學等領域之藥物動力學研究。

1. 利用微透析取樣技術以及高效液相層析法結合化學偵測法,可應用於神經傳遞物質之監測,例如:dopamine, serotonin 與其代謝物3,4-dihydroxyphenylacetic acid, homovanillic acid 5-hydroxyindoleacetic acid 之分析。此方法可應用於神經退化性疾病、行為科學與其他相關之神經藥理學研究。

 

1-1. 微透析技術與藥物動力學研究的學術成果表現

  1. 建立微透析技術應用於藥物動力學研究,擔任主篇Editor, Applications of microdialysis in pharmaceutical science. John Wiley & Sons, Inc.
  2. 首創微透析藥物動力學理論,應用於中醫針灸研究,於2004年發表第一篇針灸與藥物交互作用的論文於Tseng, T.Y., Tsai, T.H.* (2004) Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence by the acupuncture. Analytica Chimica Acta. 517:47-52.接著於2013年發表針灸和電針與藥物的交互作用研究,Wu, M.T., Shaw, L.H., Wu, Y.T., Tsai, T.H.* (2013) Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats. Evidence-Based Complementary and Alternative Medicine. 2013: 670858.在動物實驗的研究結果皆證實,針灸的作用機轉可能不影響藥物的吸收、分布、代謝、和排泄。
  3. 首創微透析技術,應用於藥物腸肝循環研究,該理論基礎是源發於1921年,德國科學家Otto Loewi的實驗(圖一),他設計以電刺激離體青蛙心臟的迷走神經(有電刺激的璃體心臟命名為Donor heart),結果發現心跳變慢,接著收集電刺激心臟所流出的組織液,滴到另一顆沒有刺激迷走神經的離體心臟(沒有電刺激的璃體心臟命名為recipient heart),得到相同的結果,心跳也變慢。當時他下了一個結論,當以電刺激離體青蛙心臟的迷走神經時,有物質釋放出來,而這個物質會讓心跳變慢。直到1936年這物質終於被研究出來,就是乙醯膽鹼(acetylcholine)Otto Loewi也因此獲得諾貝爾獎。

 

圖一: Otto Loewi離體青蛙心臟實驗圖。

我們的實驗設計也採用donor rat recipient rat的概念,donor rat是有給藥的大鼠,recipient rat是沒有給藥的大鼠(圖二)。手術時將donor rat的膽汁引流到recipient rat,如藍線所示,紅線是為了平衡donor rat的膽汁流失和recipient rat的膽汁增加,兩隻大鼠的頸靜脈都插上微透析探針。

 

 

圖二: 藥物進行腸肝循環的實驗設計。

 

如果藥物自donor rat的股靜脈注射後,藥物能在recipient rat頸靜脈上的微透析探針能收集到,則可證實在recipient rat的藥物來自donor rat的膽汁排泄,進入recipient rat的十二指腸,吸收後進入體循環。這項實驗設計首先發表在20082011Chen, Y.J., Huang, S.M., Liu, C.Y., Yeh, P.H., Tsai, T.H.* (2008) Hepatobiliary excretion and enterohepatic circulation of colchicine in rats. International Journal of Pharmaceutics. 350, 230-239. Tsai, T.H. (2011) Editor, Applications of microdialysis in pharmaceutical science. John Wiley & Sons, Inc.

 

2. 藥物進行淋巴吸收的研究:1995年左右英國發生狂牛症時,牛肉變成是禁忌,但如果牛肉之類的蛋白質也循,蛋白質在體內分解成小胜肽、或胺基酸,則這塊狂牛症的病態蛋白應該被分解才對,但事實上可能沒有被分解,因此我們試著以淋巴吸收來解釋(圖三)

 

圖三: 大鼠的淋巴手術圖。

 

我們在2010年首先提出這項假說,當時也受德國兩位教授Ranier Cermak (Leipzig university) and Segfried Wolffram (Kiel university)的質疑,我們也進行反駁(Rebuttal),結果都登錄在這兩篇文章,Chen, I.L., Tsai, Y.J., Huang, C.M., Tsai, T.H.* (2010) Pharmacokinetics of quercetin in rat plasma and lymph on a mesenteric lymphatic-cannulated model. Journal of Agricultural and Food Chemistry. 58:546-551. Tsai, T.H.*, Chen, I.L. (2010) Rebuttal to a comment on lymphatic absorptions of quercetin and rutin in the rat and their pharmacokinetics in systemic plasma. Journal of Agricultural and Food Chemistry. 58, 8468-8469.接著,在2012本研究室又發表一篇專文支持淋巴吸收假說。Tsai, Y.J., Tsai, T.H.* (2012) Mesenteric lymphatic absorption and the pharmacokinetics of naringin and naringenin in the rat. Journal of Agricultural and Food Chemistry. 60, 12435-12442.

 

3. 藥物通過胎盤的研究: 2009922日台東有一位懷孕的婦女,被證實感染H1N1病毒,但是她拒絕服藥,因為擔心藥物會對她的胎兒產生毒性,過幾天後,不幸這位媽媽和胎兒都死亡。

 

圖四: 在懷孕大鼠投與oseltamivir (10 mg/kg, iv)oseltamivir and oseltamivir carboxylic acid在母體、胎盤、羊水、和胎兒的濃度。

 

於是本研究室設計以懷孕大鼠當實驗模式,探討抗病毒藥物oseltamivir自母體通過胎盤、羊水、到胎兒的研究。結果發現毒性較強的代謝物oseltamivir carboxylic acid,在胎兒只有在母體的1.9 %,這項結果於2012年發表於PLOS ONE

Lin, C.C., Yen, J.C., Wu, Y.T., Lin, L.C., Tsai, T.H.* (2012) Chemical analysis and transplacental transfer of oseltamivir and oseltamivir carboxylic acid in pregnant rats. PLOS ONE. 7(10): e46062.

 

4. 自由態(free-form)藥物之藥物動力學:

傳統藥物動力學研究藉由監測血漿或者血清中之總體(total-form)藥物分子,無法區分與血中蛋白的結合態(bound-form)與自由態(free-form)藥物分子。然而,僅自由態藥物能到達標地(targetsite)並產生藥物作用。以抗生素為例,監測血中藥物濃度並無法適切地反應週邊組織之藥物濃度。因此本實驗室以活體微透析技術(in vivo microdialysis)進行自由態藥物之藥物動力學研究,例如:gastrodin及其代謝物p-hydroxybenzyl alcohol (Lin et al., 2008)kadsurenone (Huang et al., 2009)clenbuterol (Chang et al., 2009)hydroxytyrosol (Wu et al., 2009)5-Fluorouracil (Hsieh etal., 2010)adenosine and cordycepin (Tsai et al., 2010)aspirinsalicylic acid (Shaw et al., 2012)等。

 

5. 藥物之膽汁排泄:

乳薊是一種具有保護肝臟作用的草藥,而 silibinin 是乳薊萃取物silymarin 中的主成分之一。我們探討了silibinin的膽汁排泄和生體可利用率(bioavailability),並且比較在正常大鼠與肝硬化大鼠兩者之間的藥物動力學是否有所不同(Wu et al., 2008)。探討天麻中gastrodin及其代謝物p-hydroxybenzyl alcohol的膽汁排泄(Lin et al., 2008)

 

6. 藥物交互作用探討:

藥物交互作用的產生可能導致治療失敗,或者造成嚴重的副作用產生。為了評估臨床用藥與中草藥並用的安全性,我們進行了一系列的探討,包括(-)-epigallocatechin-3-gallateirinotecan (Lin et al., 2008)silymarintrazodone (Chang et al., 2009) Andrographis paniculata extract, andrographolidetheophylline (Jian et al., 2010)等臨床用藥與中草藥的交互作用評估。

 

7. 中草藥之代謝與排泄探討:

在吳茱萸的研究中,我們探討Dehydroevodiamine的藥物動力學以及其尿液中的代謝物Dehydroevodiamine (Lin et al., 2012)

 

8. 標靶藥物與中草藥之交互作用:

近年來,肝癌治療偏向標靶藥物治療,例如: sorafenib。目前對於中草藥物輔助標靶藥物治療甚少,因此,我們探討龍膽瀉肝湯與標靶藥sorafenib的交互作用。

Ting, C.-T.; Cheng, Y.-Y.; Tsai, T.-H. (2017) Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats. Molecules, 22, 1034.

 

9. 藥物動力學與藥物效力學的探討(PK/PD study)

利用已建立的大鼠疾病動物模式同時探討藥物動力學與藥物效力學。例如:以大鼠肝臟缺血再灌流的動物模式,探討龍膽草中的活性成分gentiopicroside在疾病模式下的藥物動力學(Chang-Liao et al., 2012)

 

10. 藥物劑型的開發:

利用不同劑型包覆藥物進而探討其藥物動力學。例如:lovastatin (Chen et al., 2010)curcumin。將薑黃素(curcumin)以不同劑型作包覆研究其藥物動力學、吸收與分佈以及是否增加口服身體可用率(Tsai et al., 2011; Tsai et al., 2012)

Chang, L.W., Hou, M.L., Lin, L.C., Tsai, T.H.* (2015) Healthy supplements of silymarin and aqueous extract of Salvia miltiorrhiza on the pharmacokinetic interaction of lamivudine in rats. Journal of Functional Food. 17, 163–171.

Chang, L.W., Hou, M.L., Hung, S.H., Lin, L.C., Tsai, T.H.* (2015) The pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging. International Journal of Nanomedicine.

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